Inhibitory effect of the probiotic bacteria, <i>Weissella cibaria</i> CMU on halitosis: a randomized placebo-controlled study

Kim, Da-Hui; Kang, Mi‐Sun; Yeu, Ji-Eun; Gu, Lee Myung; Cho, Ja-Won

doi:10.11149/jkaoh.2020.44.4.246

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…With regard to VSC, six articles determined VSC concentrations, with three studies detecting the p values of VSC and subgroups (H 2 S, CH 3 SH and C 2 H 6 S). 49 57 60 According to the results, only two studies 57 60 reported a significant improvement in VSC levels in the experimental groups compared with the placebo groups.…”

Section: Resultsmentioning

confidence: 97%

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Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis

Huang

Xiao

et al. 2022

BMJ Open

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BackgroundHalitosis is defined as a foul odour emitted from the oral cavity. Many interventions have been used to control halitosis from mouthwashes to chewing gums. Probiotics have been reported as an alternative method to alleviate halitosis.ObjectiveThe present study aimed to investigate the effect of probiotics on halitosis from a time perspective.Design and methodsThis is a meta-analysis study performed in indexed databases up to February 2021. Randomised controlled trials that compared the effects of probiotics and placebo on primary outcomes (organoleptic (OLP) scores and volatile sulfur compound (VSC) levels) and secondary outcomes (tongue coating scores (TCS) and plaque index (PI)) were included. Data extraction and quality assessment were conducted independently by two reviewers. Publication bias and leave-one-out analyses were performed.ResultsThe standardised mean difference (SMD) and 95% CI were calculated to synthesise data. The data were subgrouped and analysed in the short term (≤4 weeks) and long term (>4 weeks) based on the follow-up time. Seven articles were included in this meta-analysis. The primary outcomes, OLP scores (SMD=−0.58; 95% CI −0.87 to –0.30, p<0.0001) and VSC levels (SMD=−0.26; 95% CI −0.51 to –0.01, p=0.04), both decreased significantly in the probiotics group compared with the placebo group in the short term. However, a significant reduction was observed only in OLP scores (SMD=−0.45; 95% CI −0.85 to –0.04, p=0.03) in the long term. No significant differences were observed in secondary outcomes. There was no evidence of publication bias. The leave-one-out analysis confirmed that the pooled estimate was stable.ConclusionsAccording to the results of this work, it seems that probiotics (eg,Lactobacillus salivarius,Lactobacillus reuteri,Streptococcus salivariusandWeissella cibaria) may relieve halitosis in the short term (≤4 weeks). The results of the biased assessment, limited data and heterogeneity of the clinical trials included might reduce the reliability of the conclusions.

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Section: Resultsmentioning

confidence: 97%

“…In one study with three observation periods, the values at 4 weeks were analysed in the short term to be consistent with that of the other studies. 49 Study heterogeneity was evaluated using Q statistics and the I 2 test. A p value <0.10 was treated as the standard test.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis

Huang

Xiao

et al. 2022

BMJ Open

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“…W. cibaria produces hydrogen peroxide, which competes with secondary colonizers for attachment sites in the mouth. This competition reduces the reservoir of periodontal pathogens that produce volatile sulfur compounds and subgingival plaque (Kim et al, 2020).…”

Section: Probiotics In Halitosismentioning

confidence: 99%

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Petrariu,

Barbu,

Niculescu

et al. 2024

Front. Microbiol.

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The imbalance of microbial composition and diversity in favor of pathogenic microorganisms combined with a loss of beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known for their capacity to improve health by stimulating the indigenous gut microbiota, enhancing host immunity resistance to infection, helping digestion, and carrying out various other functions. Concurrently, the metabolites produced by these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, and hydrogen peroxide, contribute to inhibiting a wide range of pathogenic bacteria. This review presents an update on using probiotics in managing and treating various human diseases, including complications that may emerge during or after a COVID-19 infection.

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The efficacy of probiotics in the management of intra-oral halitosis: a systematic review

Tay

2022

Clin Oral Invest

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Inhibitory effect of the probiotic bacteria, Weissella cibaria CMU on halitosis: a randomized placebo-controlled study

Cited by 4 publications

References 21 publications

Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis

Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis

Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

The efficacy of probiotics in the management of intra-oral halitosis: a systematic review

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