Inhibitory Effect of the Norlignan 2-(2′-Hydroxy-4′,6′-dimethoxyphenyl)-5-[(E)-propenyl]benzofuran fromKrameria tomentosaon Acetylcholine-Induced Relaxation of the Rat Aorta

Castro, Janiza C. M. de; Silva, Marcelo S.; Côrtes, Steyner F.; Lemos, Virgı́nia S.

doi:10.1055/s-2005-873179

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Lignan-type compounds have been isolated from different species of Krameria [27,28,41,42]. Considering the antioxidant activity, the content of total phenols, flavonoids and antiproliferative activity observed in the methanolic extract of K. erecta , it is likely that these biological activities are related to the presence of lignan-type compounds already observed in other species of the genus.…”

Section: Resultsmentioning

confidence: 99%

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

Manuel

Velázquez-Contreras

Garibay‐Escobar

et al. 2013

BMC Complement Altern Med

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BackgroundThe aim of this study, is to investigate the in vitro antioxidant activity, the total phenols content, the flavonoids content and the antiproliferative activity of methanolic extracts of the plants: Krameria erecta, Struthanthus palmeri, Phoradendron californicum, Senna covesii and Stegnosperma halimifolium, used by different ethnic groups from northwestern Mexico in the treatment and cure of various diseases.MethodsThe in vitro antioxidant activity was measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing/Antioxidant Power assay (FRAP), the total phenols content was measured by Folin–Ciocalteau assay, the flavonoids content by the AlCl3 colorimetric method and the antiproliferative activity (line cells HeLa, RAW 264.7, M12Ak.C3.F6 and L929) using MTT method.ResultsThe K. erecta extract showed the higher radical scavenging activity (67.88%), antioxidant activity by FRAP (1.41 mg Trolox Eq), the highest total phenols content (598.51 mg Galic Acid Eq/g extract), the highest flavonoids content (3.80 mg Quercetin Eq/g extract) and the greatest antiproliferative activity in a dose dependent manner against most Cell line evaluated. A positive correlation was found between the antioxidant activity and the flavonoids content.ConclusionsThis study is the first report on the antioxidant and antiproliferative activities of the five species evaluated. The results demostrate that there is a positive correlation between antioxidant activity and the flavonoids content, indicating that these type of polyphenols could be the major contributors to the observed antioxidant activity in the evaluated plant extracts. Of the extracts evaluated, that of Krameria erecta showed the greatest antioxidant and antiproliferative activities, a discovery that makes this species a promising candidate for future research.

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Section: Resultsmentioning

confidence: 99%

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

Manuel

Velázquez-Contreras

Garibay‐Escobar

et al. 2013

BMC Complement Altern Med

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“…This effect is concentration-dependent. Moreover, the compound inhibits basal nitric oxide production [118].…”

Section: Vascularmentioning

confidence: 99%

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

et al. 2020

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In this review article, the occurrence of nor-lignans and their biological activities are explored and described. Nor-lignans have proven to be present in several different families also belonging to chemosystematically distant orders as well as to have many different beneficial pharmacological activities. This review article represents the first one on this argument and is thought to give a first overview on these compounds with the hope that their study may continue and increase, after this.

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“…This effectis concentration-dependent. Moreover, the compound inhibits basal nitric oxide production[116].…”

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confidence: 99%

Nor-Lignans: Occurrence in Plants and Biological Activities - A Review

Frezza¹,

Venditti²,

Toniolo³

et al. 2019

Preprint

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Inhibitory Effect of the Norlignan 2-(2′-Hydroxy-4′,6′-dimethoxyphenyl)-5-[(E)-propenyl]benzofuran fromKrameria tomentosaon Acetylcholine-Induced Relaxation of the Rat Aorta

Cited by 4 publications

References 8 publications

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

<em>Nor</em>-Lignans: Occurrence in Plants and Biological Activities - A Review

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