Inhibitory effect of sulfated polysaccharide from Sargassum thunbergii in PA-induced lipid accumulation in vitro

Lee, Hyo-Geun; Kang, Min‐Cheol; Jeon, You‐Jin; Kim, Young-Sang

doi:10.1016/j.fbio.2022.102144

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Its IC 50 (3.353 μg/mL) was significantly lower than that of the positive control, suggesting that the sulfate-modified polysaccharide was more effective in lowering blood glucose . Sulfate-modified polysaccharides exerted hypolipidemic effects by regulating proteins associated with lipolysis and free fatty acids oxidation, reducing intracellular lipid accumulation . Carboxymethylated polysaccharides exhibit intense lipid, bile acid, and cholesterol binding properties, which are strengthened as carboxymethylation levels increase.…”

Section: Effect Of Structural Modifications On the Biological Activit...mentioning

confidence: 99%

“…85 Sulfate-modified polysaccharides exerted hypolipidemic effects by regulating proteins associated with lipolysis and free fatty acids oxidation, reducing intracellular lipid accumulation. 86 Carboxymethylated polysaccharides exhibit intense lipid, bile acid, and cholesterol binding properties, which are strengthened as carboxymethylation levels increase. Through interactions with positively charged biomolecules, carboxymethylation, a crucial component in increasing its critical capacity, is a preventative agent against hyperlipidemia and hypercholesterolemia.…”

Section: Effect Of Physical Modifications On the Hypoglycemic And Hyp...mentioning

confidence: 99%

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Structurally Modified Polysaccharides: Physicochemical Properties, Biological Activities, Structure–Activity Relationship, and Applications

Chen,

Zhang,

Chen

2024

J. Agric. Food Chem.

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Polysaccharides are an important class of biomolecules derived from several sources. However, the inherent structure of polysaccharides prevents them from exhibiting favorable physicochemical properties, which restricts their development in agriculture, industry, food, and biomedicine. This paper systematically summarizes the changes in the primary and advanced structures of modified polysaccharides, and focuses on the effects of various modification methods on the hydrophobicity, rheological properties, emulsifying properties, antioxidant activity, hypoglycemic, and hypolipidemic activities of polysaccharides. Then there is a list the applications of modified polysaccharides in treating heavy metal pollutants, purifying water resources, improving beverage stability and bread quality, and precisely delivering the drug. When summarized and reviewed, the information above can shed further light on the relationship between polysaccharide structure and function. Determining the structure–activity relationship provides a scientific basis for the direction of molecular modifications of polysaccharides.

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Section: Effect Of Structural Modifications On the Biological Activit...mentioning

confidence: 99%

Section: Effect Of Physical Modifications On the Hypoglycemic And Hyp...mentioning

confidence: 99%

Structurally Modified Polysaccharides: Physicochemical Properties, Biological Activities, Structure–Activity Relationship, and Applications

Chen,

Zhang,

Chen

2024

J. Agric. Food Chem.

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Sulfated Polysaccharides with Anticoagulant Potential: A Review Focusing on Structure‐Activity Relationship and Action Mechanism

Chen,

Zhang,

Liu

et al. 2024

Chemistry & Biodiversity

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Thromboembolism is the culprit of cardiovascular diseases, leading to the highest global mortality rate. Anticoagulation emerges as the primary approach for managing thrombotic conditions. Notably, sulfated polysaccharides exhibit favorable anticoagulant efficacy with reduced side effects. This review focuses on the structure‐anticoagulant activity relationship of sulfated polysaccharides and the underlying action mechanisms. It is concluded that chlorosulfonicacid‐pyridine method serves as the preferred technique to synthesize sulfated polysaccharides. The anticoagulant activity of sulfated polysaccharides is linked to the substitution site of sulfate groups, degree of substitution, molecular weight, main side chain structure, and glycosidic bond conformation. Moreover, sulfated polysaccharides exert anticoagulant activity via various pathways, including the inhibition of blood coagulation factors, activation of antithrombin III and heparin cofactor II, antiplatelet aggregation, and promotion of the fibrinolytic system.

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Study on gender differences between male and female Sargassum thunbergii based on metabolomic analysis and physiological functions

Qiu,

Sun,

et al. 2023

Algal Research

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Inhibitory effect of sulfated polysaccharide from Sargassum thunbergii in PA-induced lipid accumulation in vitro

Cited by 6 publications

References 19 publications

Structurally Modified Polysaccharides: Physicochemical Properties, Biological Activities, Structure–Activity Relationship, and Applications

Structurally Modified Polysaccharides: Physicochemical Properties, Biological Activities, Structure–Activity Relationship, and Applications

Sulfated Polysaccharides with Anticoagulant Potential: A Review Focusing on Structure‐Activity Relationship and Action Mechanism

Study on gender differences between male and female Sargassum thunbergii based on metabolomic analysis and physiological functions

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