Inhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation

Mei, May Lei; Ito, Leticia; Cao, Ying; Li, Q.L.; Lo, Edward Chin Man; Chu, Chun Hung

doi:10.1016/j.jdent.2013.06.009

Cited by 220 publications

(240 citation statements)

References 29 publications

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“…An increase in the mineral density and in the hardness of the carious dentin was observed in vitro [Mei et al, 2013], which is consistent with dentin remineralization [Mei et al, 2013]. SDF also inhibits the breakdown of the exposed collagen matrix, since it inhibits matrix metalloproteinases and cysteine cathepsins [Mei et al, 2013], probably due to the high concentration of silver [Thanatvarakorn et al, 2016].…”

Section: Discussionsupporting

confidence: 65%

Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

Chibinski

Wambier²,

Feltrin³

et al. 2017

Caries Res

147

175

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A systematic review was performed to evaluate the efficacy of silver diamine fluoride (SDF) in controlling caries progression in children when compared with active treatments or placebos. A search for randomized clinical trials that evaluate the effectiveness of SDF for caries control in children compared to active treatments or placebos with follow-ups longer than 6 months was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library, and grey literature. The risk of bias tool from the Cochrane Collaboration was used for quality assessment of the studies. The quality of the evidence was evaluated using the GRADE approach. Meta-analysis was performed on studies considered at low risk of bias. A total of 5,980 articles were identified. Eleven remained in the qualitative synthesis. Five studies were at “low,” 2 at “unclear,” and 4 studies at “high” risk of bias in the key domains. The studies from which the information could be extracted were included for meta-analysis. The arrestment of caries at 12 months promoted by SDF was 66% higher (95% CI 41-91%; p < 0.00001) than by other active material, but it was 154% higher (95% CI 67-85%; p < 0.00001) than by placebos. Overall, the caries arrestment was 89% higher (95% CI 49-138%; p < 0.00001) than using active materials/placebo. No heterogeneity was detected. The evidence was graded as high quality. The use of SDF is 89% more effective in controlling/arresting caries than other treatments or placebos. The quality of the evidence was graded as high.

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Section: Discussionsupporting

confidence: 65%

Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

Chibinski

Wambier²,

Feltrin³

et al. 2017

Caries Res

147

175

View full text Add to dashboard Cite

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“…5) 29) . Previous study comparing the anti-degradation efficacy among the 38% SDF, 10% NaF, 42% AgNO 3, and water (Control) showed that both SDF and AgNO3 similarly exhibited better efficacy compared to Control; whereas NaF did not 30) . There was a concern that no direct comparison was performed between 30-s immersion and 24-h immersion in the Control group.…”

Section: Discussionmentioning

confidence: 92%

Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents

et al. 2016

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Root caries is developed because of demineralization followed by enzymatic collagen degradation. This in vitro study aimed to examine the inhibitory efficacy of ZnF2 on dentin demineralization and collagen degradation. Bovine dentin specimens were treated either with ZnF2 or HCl-acidified ZnF2 (ZnF2/HCl) and then demineralized. Anti-demineralization efficacy was assessed by TMR as mineral loss (ΔZ). The efficacy was compared with silver diammine fluoride (SDF), KF, and acidulated phosphate fluoride (APF). For evaluating anti-collagen degradation, EDTA-demineralized dentin specimens were treated by one of four fluoride agents [SDF, APF, ZnF2/HCl, NaF] followed by collagenase challenge. The eroded depth of collagen layer in the lesion was assessed using optical microscope. ΔZ of SDF, KF, ZnF2/HCl, and APF were significantly lower compared with ZnF2 and Control (no treatment). Regarding anti-collagen degradation, SDF and ZnF2/HCl demonstrated a significant difference in the eroded depth compared with Control. Although SDF possessed higher efficacy, ZnF2/HCl might be beneficial as a staining-free agent.

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“…17,18 Regarding the effectiveness of different of SDF application protocols, this study showed that a one-off intensive SDF application protocol with 3 weekly applications 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 can lead a higher proportion of active dentine lesions in primary teeth being arrested in the short-term (within a year) and provide an outcome not significantly different from that of annually repeated applications in the longer term (18 months). It seems that either of the two SDF application protocols can be adopted when a non-restorative treatment approach is chosen for managing dentine caries in primary teeth.…”

Section: Discussionmentioning

confidence: 99%

A randomized clinical trial on arresting dentine caries in preschool children by topical fluorides—18 month results

Duangthip

Chu

2016

Journal of Dentistry

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124

154

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Inhibitory effect of silver diamine fluoride on dentine demineralisation and collagen degradation

Cited by 220 publications

References 29 publications

Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents

A randomized clinical trial on arresting dentine caries in preschool children by topical fluorides—18 month results

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