Abstract:The inhibition of CH50, a recombinant polypeptide of human fibronectin, on the formation of tumor metastases in vivo was studied by inoculation of melanoma B16/F1 cells by hypodermic or intraperitoneal injection, and the size and amount of tumor nodes after therapy were measured. In the treatment of hypodermic tumor, local injection of CH50 produced much better efficacy than distance injection of CH50 did. The inhibitory effect of CH50 on the growth of tumor reached 50%. In the treatment of peritoneal metastas… Show more
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