Inhibitory effect of quercetin on carrageenan-induced inflammation in rats

Morikawa, Keiko; Nonaka, Mitsuko; Narahara, Misa; Torii, Ikuko; Kawaguchi, Kiichiro; Yoshikawa, Takafumi; Kumazawa, Yoshio; Morikawa, Shigeru

doi:10.1016/j.lfs.2003.06.036

Cited by 170 publications

(108 citation statements)

References 23 publications

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“…On the other hand, the pharmacological effect produced by the flavonoid is quite different, and treatment with a certain flavonoid may affect, at least in part, some inflammatory responses in many situations [26,27]. The results of the present study are comparable with those observed with quercetin, another potent flavonoid that prevents further recruitment of inflammation cells to the site of inflammatory response [28]. All these including the present study, proved that several flavonoids including silibinin really inhibit the expression of pro-inflammatory molecules [29] in experimental animal models and human studies.…”

Section: Discussionsupporting

confidence: 79%

Anti-Inflammatory Activity of Silibinin in Animal Models of Chronic Inflammation

Aziz¹,

Marouf²,

Ahmed³

et al. 2014

AJPS

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Attenuation of the chronic inflammatory response is a beneficial strategy to combat several human diseases. Traditional medicine offers many plant extracts and pure natural compounds as treatment options of a wide variety of disorders including acute and chronic inflammation. The present study was designed to evaluate the antiinflammatory effect of silibinin in experimental animal models of chronic and granulomatous inflammations. Fortyeight rats were used to induce chronic inflammation in the hind paw with formalin and granulomatous inflammation with sterile cotton pellets. The anti-inflammatory activity of silibinin (300 mg/kg, P.O) was evaluated in the two models, and compared with that produced by dexamethasone (1 mg/kg, P.O). Silibinin decreased significantly the formation of exudate and granulation tissue compared with the vehicle, but still significantly lower than that produced by dexamethasone. In conclusion, our data suggest that silibinin inhibits the production of edema and granulation tissue in experimental animal models of chronic inflammation, and could be a potential choice for the treatment of chronic inflammatory disorders.

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Section: Discussionsupporting

confidence: 79%

Anti-Inflammatory Activity of Silibinin in Animal Models of Chronic Inflammation

Aziz¹,

Marouf²,

Ahmed³

et al. 2014

AJPS

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“…Quercetin presents various pharmacological effects, such as antioxidative (Gomes et al, 2014;Yang et al, 2014), anti-inflammatory (Morikawa et al, 2003), antidiabetic (Vessal et al, 2003), and antiobesity effects (Ahn et al, 2008). Quercetin was reported to inhibit the activation of NFkB and p38 mitogen-activated protein kinase in calcium ionophore A23187-stimulated human mast cell line HMC-1 cells (Min et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

Zhang

Lin

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Quercetin, a dietary flavonoid abundant in fruits, vegetables, and herbs, presents various pharmacological effects. This study aimed to investigate the anti-inflammatory effect and the underlying mechanism of quercetin in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs). Cell viability was measured by the Cell Counting Kit-8 assay. The mRNA expression of Toll-like receptor 2 (TLR2) was assessed by quantitative real-time polymerase chain reaction. Inflammatory cytokine secretions and nuclear factor (NF)-kB levels were analyzed by enzyme-linked immunosorbent assay. Our findings showed that quercetin significantly reduced LPS-induced cytotoxicity in human PBMCs. Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs. Moreover, quercetin reduced the LPS-induced increase in the expression of TLR2 mRNA and decreased the NF-kB concentration in LPS-stimulated human PBMCs. The data indicates that quercetin plays an important role in

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“…These three compounds were selected to represent molecule with aromatic and carbonyl chromophores which have π  π* and n  π* electronic transitions (quercetine), a molecule which lacks of the chromophore (glucosamine), and molecule without aromatic chromophore (andrographolide). These three compounds have been proven to show anti-inflammatory activity in animals [3][4][5][6][7][8]. …”

Section: Introductionmentioning

confidence: 99%

Prediction of Log P and Spectrum of Quercetine, Glucosamine, and Andrographolide and Its Correlation With Laboratory Analysis

Megantara

Mutakin

Levita

2016

Int J Pharm Pharm Sci

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Objective: This study was aimed to confirm the result of computational prediction of log P and spectrum 13 Methods: Quercetine, glucosamine and andrographolide, were downloaded from ChemSpider and were geometry optimised. Log P and spectrum were calculated and predicted and the data obtained were compared with laboratory results. The correlation was calculated by employing mean absolute deviation (MAD), mean square error (MSE), mean forecast error (MFE), and mean absolute percentage error (MAPE) parameters.C-NMR) of quercetin, glucosamine and andrographolide with laboratory analysis.Results: The smallest energy value of geometry optimisation was provided by ab initio method. Log P prediction showed good accuracy, with r-value 0.995 and p-value 0.05 respectively. The error parameters were: MAD 0.19; MSE 0.06; MFE 0.16, and MAPE 8.62%, respectively. Prediction of λ maximum by ab initio, semiempirical, and molecular mechanics were respectively: MAD 2. 67, 6.67, and 28.67; MSE 8.67, 45.33, and 830; MFE 2.67, 6.67, and 28.67; and MAPE 1.10%, 2.79%, and 11.99%; r-value 0.997, 0.997, and 0.979; and p-value 0.044, 0.043, and 0.129. 1 H-NMR and 13Conclusion: There is a positive correlation between computational ab initio calculation method with experimental results in predicting log P and spectrum of quercetine, glucosamine, and andrographolide.C-NMR spectra prediction were: MAD 0.73 and 1.58; MSE 1.15 and 7.41; MFE 0.27 and 0.69; MAPE 18.35% and 2.68%; r-value 0.942 and 0.986; and p-value 0.001 and 0.001.

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Inhibitory effect of quercetin on carrageenan-induced inflammation in rats

Cited by 170 publications

References 23 publications

Anti-Inflammatory Activity of Silibinin in Animal Models of Chronic Inflammation

Anti-Inflammatory Activity of Silibinin in Animal Models of Chronic Inflammation

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

Prediction of Log P and Spectrum of Quercetine, Glucosamine, and Andrographolide and Its Correlation With Laboratory Analysis

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