Inhibitory Effect of Quercetin on Propionibacterium acnes-induced Skin Inflammation

Lim, Hyeon-Ji; Kang, Seungwoo; Song, Yun Heub; Jeon, Yong-Deok; Jin, Jong-Sik

doi:10.1016/j.intimp.2021.107557

Cited by 39 publications

(28 citation statements)

References 47 publications

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“…In vitro experiments proved that quercetin suppressed MMP-9 in two cell lines exposed to P . acnes [ 27 ]. Kaempferol exerts an inhibitory effect on ERK1/2 phosphorylation [ 41 ] and prostaglandin synthesis by suppressing COX-1 and COX-2 enzyme activity [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Compared with the other compounds, quercetin had the highest degree value in the network. is compound also exhibits an inhibitory effect on proinflammatory cytokines and chemokines such as IL1β, IL8, IL6, and TNF-α from P. acnes-stimulated human keratinocytes and monocytes [27]. Kaempferol has a moderate antibacterial activity and an inhibitory effect on P. acnes growth [28,29].…”

Section: Erapeutic Effect Of the Main Active Compounds Of The Jgl For...mentioning

confidence: 99%

“…Quercetin significantly suppresses the secretion of proinflammatory cytokines IL8, IL1ß, IL6, and TNF-α in P. acnes-stimulated cells and the phosphorylation of JNK, ERK, and p38 MAPK signalling pathways and the production of TLR-2 in P.acnes-stimulated human keratinocytes and THP-1 cells. In vitro experiments proved that quercetin suppressed MMP-9 in two cell lines exposed to P. acnes [27]. Kaempferol exerts an inhibitory effect on ERK1/2 phosphorylation [41] and prostaglandin synthesis by suppressing COX-1 and COX-2 enzyme activity [28].…”

Section: Antiinflammatory Effect Of the Jgl Formula Throughmentioning

confidence: 99%

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Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris

Gholais

Shi

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. JinGuanLan (JGL) formula is a traditional Chinese medicine (TCM) developed by the Department of Pharmacology at the First Hospital of Lanzhou University. The network pharmacology approach was applied to determine the potential active compounds, therapeutic targets, and main pathways of the JGL formula to evaluate its application value in acne vulgaris. Methods. Data on the active compounds and their related targets were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Acne vulgaris-related targets were searched from the Online Mendelian Inheritance in Man (OMIM) database, GeneCards Database, Comparative Toxicogenomics Database (CTD), Therapeutic Target Database (TTD), and DisGeNET Database. Targets intersecting between JGL- and acne vulgaris-related targets were chosen as potential therapeutic targets. The protein-protein interaction (PPI) network of potential therapeutic targets was visualized using Cytoscape software based on the PPI data collected from the STRING database. Three topological features, namely, “Degree,” “MCC,” and “EPC” of each node in the PPI network were calculated using the cytoHubba plugin of Cytoscape to excavate the core targets. R program was used for the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the potential therapeutic targets. Finally, the compound–target–pathway network was constructed. Result. Among the 148 active compounds that were identified, quercetin and kaempferol showed the highest degree of target interaction and thus may play essential roles in the pharmacological effect of the JGL formula for acne treatment. Among the 97 potential therapeutic targets that were screened out, the 6 core targets were TNF, JUN, IL6, STAT3, MAPK1, and MAPK3. A total of 2260 terms of GO enrichment analysis were obtained, including 2090 for biological processes (BP), 37 for cellular components (CC), and 133 for molecular function (MF). A total of 156 enriched KEGG pathways were identified, including TNF, IL-17, Th17 cell differentiation, MAPK, PI3K-Akt, T cell receptor, and Toll-like receptor signalling pathways. Conclusion. This work showed that the JGL formula might reverse the pathological changes associated with acne vulgaris through its antiinflammatory effect and regulate the excessive lipogenesis in sebaceous glands via different signalling pathways. This new drug has application value and is worthy of further research and development.

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Section: Discussionmentioning

confidence: 99%

Section: Erapeutic Effect Of the Main Active Compounds Of The Jgl For...mentioning

confidence: 99%

Section: Antiinflammatory Effect Of the Jgl Formula Throughmentioning

confidence: 99%

See 1 more Smart Citation

Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris

Gholais

Shi

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Studies have shown that quercetin has broad-spectrum antibacterial activity; the antibacterial activities destroy the bacteria's cell wall and change cell permeability, affecting protein synthesis and expression, reducing enzyme activities, and inhibiting nucleic acid synthesis [5]. Lim et al (2021) [6] studied that quercetin has antibacterial activity against Propionibacterium acnes-induced skin disorders by significantly trimming down the pro-inflammatory cytokine production in various P. acnes-stimulated cell lines by reducing the TLR-2 expression, matrix metalloproteinase-9 (MMP-9) mRNA levels, and phosphorylation of mitogen-activated protein kinase (MAPK). Other than that, Vipin et al (2019) [7] stated that quercetin completely inhibited virulence factors, including biofilm formation, and showed a significant protective effect on HEK 293T cells infected with P. aeruginosa strains.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Chrismaurin

DWIASTUTI²,

Chabib³

et al. 2023

Int J App Pharm

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Objective: This research aims to evaluate the effect of olive oil, tween 60, and span 20 on the physical properties of quercetin nanoemulgel. Methods: In this research, quercetin was formulated into nanoemulgel using a variation of olive oil, tween 60, span 20, and sodium alginate as a gelling agent. The nanoemulgel physical properties (pH, viscosity, and spreadability), stability, and particle size were tested. The data were measured and evaluated using Minitab®18 software; if the p-value<0.05, it is stated that there is a statistically significant difference in the formula. Results: The result showed that tween 60 has the greatest significant impact on pH, viscosity, and transmittance value with a p-value<0.05 for all, meanwhile span 20 has the greatest significant impact on the spreadability of the nanoemulgel preparations with a p-value<0.05 indicating that they are significantly different. Conclusion: This study reported that the effect of olive oil, tween 60 and span 20, with different variations, significantly impacts the physical properties (pH, viscosity, and spreadability) of the nanoemulgel.

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“…[4][5][6][7][8][9] For example, quercetin, a polyphenolic flavonoid compound in numerous plants, induces antiinflammatory effects by attenuating toll-like receptor (TLR) 2 pathway signaling. [10][11][12] Several key results regarding the determinants of the severity of inflammatory acne have been obtained in recent years; (1) patients with more severe acne have lower C. acnes strain diversity than healthy individuals and (2) the relative abundance of C. acnes in metagenomic studies is similar in patients with acne and healthy individuals (though there are some reports of slightly higher levels in healthy individuals), indicating that C. acnes overgrowth is not associated with the severity of acne. [13][14][15] In other words, a loss of diversity in the skin surface microbiome and loss of balance between C. acnes phylotypes are thought to trigger acne.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon (Citrullus lanatus) Fruit Have Beneficial Effects Against Cutibacterium acnes-Induced Skin Inflammation

Itoh

Muramatsu

Miyazono

et al. 2022

Natural Product Communications

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Acne vulgaris, typically caused by Cutibacterium acnes ( C. acnes) involves chronic inflammation of the sebaceous follicles and is the most common skin disease, afflicting 85% of adolescents. We previously isolated 2 novel phenolic glycosides, 2-caffeoyl-3-hydroxy-3-methylbutyric 4′-β-D-glucopyranosyloxy-3′-hydroxybenzyl ester (citrulluside H [CH]) and 2-caffeoyl-3-hydroxy-3-methylbutyric 4′-β-d-glucopyranosyloxybenzyl ester (citrulluside T [CT]), from young fruits of watermelon ( Citrullus lanatus). Both compounds suppressed UVB-induced photoaging in human fibroblasts by scavenging intracellular reactive oxygen species (ROS) and thus might be useful as natural skin care ingredients. In this study, we examined the inhibitory effects of these phenolic glycosides on C. acnes growth and C.acnes-induced inflammation. Neither phenolic glycoside inhibited the growth of C. acnes. However, they both significantly suppressed toll-like receptor (TLR) 1/2 or TLR2/6/nuclear factor κB (NF-κB) signaling in heat-killed C. acnes (hk- C. acnes) -stimulated RAW264.7 cells. Additionally, both phenolic glycosides decreased the expression of M1 macrophage biomarkers (cluster of differentiation [ CD] 80, CD86, and inducible NO synthase [ iNOS]), suggesting that they attenuate M1 macrophage activation. These results indicated that both CH and CT are potential therapeutic substances against C. acnes-induced skin inflammation.

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Inhibitory Effect of Quercetin on Propionibacterium acnes-induced Skin Inflammation

Cited by 39 publications

References 47 publications

Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris

Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon (Citrullus lanatus) Fruit Have Beneficial Effects Against Cutibacterium acnes-Induced Skin Inflammation

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