Inhibitory Effect of Nilvadipine on Disruption of Blood-Aqueous Barrier Induced by Prostaglandin E<sub>2</sub> Application in Pigmented Rabbits: A Morphologic Study
Abstract:The purpose of the present study is to investigate the morphologic sites of breakdown in eyes pretreated with nilvadipine (a calcium channel blocker) that has been shown to inhibit the acute rise of aqueous flare induced by prostaglandin E2 (PGE2). Nilvadipine (100 µg/kg body weight) was injected intravenously in pigmented rabbits. Thirty minutes later, vehicle or PGE2 (10, 50 or 250 µg/ml) was applied on the cornea by use of a glass cylinder. Forty-five minutes later, the anim… Show more
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