Inhibitory effect of nerol against Aspergillus niger on grapes through a membrane lesion mechanism

Wang, Yanzhen; Zeng, Xiaobin; Zhou, Zhengkun; Xing, Ke; Tessema, Akalate; Zeng, Hong; Tian, Jun

doi:10.1016/j.foodcont.2015.02.029

Cited by 51 publications

(25 citation statements)

References 42 publications

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“…Moreover, the antifungal pathways of PAE must be partly explained. PAE, as a kind of EOs, may readily dissolve in biological membranes [48], and leads to a serious injury to plasma membrane through indirect interference in ergosterol biosynthesis [49], resulting in release of cytoplasmic contents into extracellular space. In fact, mitochondria is an important organelle consisting of phospholipid bilayers, and thus PAE can disturb its function, leading to abnormalities of the electron transport chain (ETC), resulting in producing numerous ROS [10].…”

Section: Discussionmentioning

confidence: 99%

The Molecular Mechanism of Perillaldehyde Inducing Cell Death in Aspergillus flavus by Inhibiting Energy Metabolism Revealed by Transcriptome Sequencing

Pan

Yang

et al. 2020

IJMS

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Perillaldehyde (PAE), an essential oil in Perilla plants, serves as a safe flavor ingredient in foods, and shows an effectively antifungal activity. Reactive oxygen species (ROS) accumulation in Aspergillus flavus plays a critical role in initiating a metacaspase-dependent apoptosis. However, the reason for ROS accumulation in A. flavus is not yet clear. Using transcriptome sequencing of A. flavus treated with different concentrations of PAE, our data showed that the ROS accumulation might have been as a result of an inhibition of energy metabolism with less production of reducing power. By means of GO and KEGG enrichment analysis, we screened four key pathways, which were divided into two distinct groups: a downregulated group that was made up of the glycolysis and pentose phosphate pathway, and an upregulated group that consisted of MAPK signaling pathway and GSH metabolism pathway. The inhibition of dehydrogenase gene expression in two glycometabolism pathways might play a crucial role in antifungal mechanism of PAE. Also, in our present study, we systematically showed a gene interaction network of how genes of four subsets are effected by PAE stress on glycometabolism, oxidant damage repair, and cell cycle control. This research may contribute to explaining an intrinsic antifungal mechanism of PAE against A. flavus.

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Section: Discussionmentioning

confidence: 99%

The Molecular Mechanism of Perillaldehyde Inducing Cell Death in Aspergillus flavus by Inhibiting Energy Metabolism Revealed by Transcriptome Sequencing

Pan

Yang

et al. 2020

IJMS

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“…Aspergillus niger contains 10% chitin in the cell wall, and fungi that have chitosan as one of their cell wall components are more resistant to externally delivered chitosan (Beauvais et al, 2014;Beauvais & Latg e, 2018). According to Wang et al (2015) and Lichter et al (2002), infection of this pathogen in fruits is characterised by softening of the infected site followed by the development of a dark mould that corresponds to the fructification structures of the fungi. These changes were more intense in uncoated and in strawberries coated with glycerol, which confirms the importance of chitosan-based edible coatings in retarding fungal growth.…”

Section: In Vivo Antifungal Effectsmentioning

confidence: 99%

In vivo and in vitro antifungal effect of fungal chitosan nanocomposite edible coating against strawberry phytopathogenic fungi

Melo

Lima

Stamford

et al. 2020

Int J of Food Sci Tech

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This study compared the effectiveness of fungal chitosan nanocomposite, chitosan gel and chitosan nanoparticles against strawberry phytopathogenic fungi (Botrytis cinerea; Rhizopus stolonifer and Aspergillus niger). Nanoparticles were prepared by ionic gelation method and characterised by dynamic light scattering and scanning electron microscopy. The influence of the edible coatings on fungal growth was analysed in vitro and in vivo The fungal chitosan nanoparticles presented an average size = 331.1 nm (AE7.21) with a narrow size distribution (PDI = 0.377) and a zeta potential = +34 mV. The edible coating made by the nanocomposite exhibited important changes in fungal morphology, and the best control of the growth of the assayed fungal strains in artificially infected strawberries. Therefore, nanotechnology brought some benefits to the conventional chitosan gel edible coating, improving its antifungal activity and forming a new eco-friendly coating.

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“…A natureza lipofílica dos OE permite que os constituintes químicos provoquem a perda instantânea da integridade da membrana, mantendo a homeostase de íons. Esse processo controla as atividades celulares, incluindo a transcrição de DNA, a síntese de proteínas e a atividade de enzimas (WANG et al, 2015).…”

Section: Atividade Antifúngica Dos óLeos Essenciaisunclassified

Anemia Hemolítica Autoimune: Introdução Á Formas De Apresentação Da Síndrome E Diagnóstico Imuno-Hematológico

Mendes¹,

Dias²,

Mendonça³

et al. 2020

Expansão Do Conhecimento E Inovação Tecnológica No Campo Das Ciências Farmacêuticas

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. A Atena Editora não se responsabiliza por eventuais mudanças ocorridas nos endereços convencionais ou eletrônicos citados nesta obra. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação.

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Inhibitory effect of nerol against Aspergillus niger on grapes through a membrane lesion mechanism

Cited by 51 publications

References 42 publications

The Molecular Mechanism of Perillaldehyde Inducing Cell Death in Aspergillus flavus by Inhibiting Energy Metabolism Revealed by Transcriptome Sequencing

The Molecular Mechanism of Perillaldehyde Inducing Cell Death in Aspergillus flavus by Inhibiting Energy Metabolism Revealed by Transcriptome Sequencing

In vivo and in vitro antifungal effect of fungal chitosan nanocomposite edible coating against strawberry phytopathogenic fungi

Anemia Hemolítica Autoimune: Introdução Á Formas De Apresentação Da Síndrome E Diagnóstico Imuno-Hematológico

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