Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT

Choi, Eun‐Ju; Kim, Min Jung; Ji, Yong-Seok; Lee, Changjin

doi:10.14480/jm.2015.13.3.170

Journal of Mushroom

2015

DOI: 10.14480/jm.2015.13.3.170

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Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT

Eun‐Ju Choi¹,

Min Jung Kim²,

Yong-Seok Ji³

et al.

Abstract: Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that the inhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To define the underlying mechanisms of action, tumor necrosis factorα/IFNγ-activated human keratinocytes model was used. Mushroom significantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibited inflammtion, suggesting that m… Show more

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Cited by 2 publications

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Skin-whitening effects of hot water extract from domestic edible mushrooms

Kim¹,

Jang²,

Park³

et al. 2016

Journal of Mushroom

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Hot water extracts from 16 domestic edible mushrooms including Pleurotus ferulae (Lanzi) X.L. Mao, Lentinula edodes (Berk.) Pegler, and Hypsizygus marmoreus (Peck) H.E. Bigelow, which are commercially available, were used for determining the cosmetic potential of these mushrooms. In this study, we carried out in vitro functional experiments to determine the inhibitory effects of these extracts on L-DOPA oxidation of tyrosinase and melanin synthesis. Based on the results of these experiments, H. marmoreus (Peck) H.E. Bigelow No. 10 and No. 15 were selected for further analysis. We analyzed the melanin synthesis inhibitory activity, TRP1 and MITF expression via real-time PCR, and Fontana Masson staining in artificial skin Neoderm®-ME. Taken together, we observed that the hot water extract from H. marmoreus (Peck) H.E. Bigelow (No. 15) had better whitening effect than the extracts of other mushrooms. Thus, it can be a potential source of skin-whitening agent.

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Skin-whitening effects of hot water extract from domestic edible mushrooms

Kim¹,

Jang²,

Park³

et al. 2016

Journal of Mushroom

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Anti-inflammatory Effects and Innate Immunity Suppression by Fritillaria ussuriensis Extracts

Seo¹,

Kim²,

Kim³

2018

Asian J Beauty Cosmetol

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Purpose: The present study aimed to evaluate the anti-inflammatory effects, innate immunity suppression, and cosmetic activity of Fritillaria ussuriensis (FU) extracts in lipopolysaccharide (LPS)-induced inflammatory mice models using serum, blood, and histological analyses. Methods: FU extracts were obtained by refluxing with 80% ethanol and used to investigate the anti-inflammatory and innate immune responses. Balb/c mice were divided into four groups: a normal group in which acute inflammation was not induced, a control group in which only distilled water was administered, and test groups in which 200 mg/kg/day and 400 mg/kg/day of FU extract were orally administered. After the administration, 1 mg/kg of LPS was injected intraperitoneally in the control and test groups but not the normal group. After 90 min, effects based on cytokine and immune cell analyses and skin histopathological analysis were evaluated. Results: Compared with the control group, the test groups showed reduced serum concentrations of inflammation markers (interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1β), and interleukin 6 (IL6)) and immune markers (white blood cell (WBC) and monocyte markers). The test groups also showed an increased number of granulocytes (neutrophils, eosinophils, and basophils). Moreover, histological examination demonstrated that the FU extract suppressed thickening of the epidermis in the test groups. Conclusion: The results indicate that FU extracts prevented and improved acute inflammation. Thus, FU extracts may be used as raw material for preparing new health foods, medicines, or cosmetics.

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Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT

Cited by 2 publications

References 4 publications

Skin-whitening effects of hot water extract from domestic edible mushrooms

Skin-whitening effects of hot water extract from domestic edible mushrooms

Anti-inflammatory Effects and Innate Immunity Suppression by Fritillaria ussuriensis Extracts

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