Inhibitory effect of moschamine isolated from Carthamus tinctorius on LPS-induced inflammatory mediators via AP-1 and STAT1/3 inactivation in RAW 264.7 macrophages

Jo, Ara; Han, Hee-Soo; Seo, Seunghwan; Shin, Ji‐Sun; Lee, Jae Yeol; Kim, Hyoung Ja; Lee, Kyung‐Tae

doi:10.1016/j.bmcl.2017.10.035

Cited by 21 publications

(13 citation statements)

References 25 publications

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“…Another study showed icariin, a flavonoid glycosides extracted from epimedium herb, promoted the expression of nNOs after neural injury (Shindel et al, 2010 ). It was also reported that cassia twig, geranium wilfordii and carthamus tinctorius had anti-inflammatory, antioxidative, neurorotective and analgesic effects (Gan et al, 2010 ; Wang et al, 2014 ; Yue et al, 2014 ; Gunawardena et al, 2015 ; Huang et al, 2015 ; Jo et al, 2017 ). According to previous study, we took 4 active ingredients of WLT as probe to conduct molecular docking with potential targets obtained from metabolomic analysis.…”

Section: Discussionmentioning

confidence: 99%

Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways

Deng

et al. 2018

Front. Pharmacol.

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Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting toxicity of many anti-neoplastic agents, especially paclitaxel, and oxaliplatin. Up to 62% of patients receiving paclitaxel regimens turn out to develop CIPN. Unfortunately, there are so few agents proved effective for prevention or management of CIPN. The reason for the current situation is that the mechanisms of CIPN are still not explicit. Traditional Chinese Medicine (TCM) has unique advantages for dealing with complex diseases. Wen-Luo-Tong (WLT) is a TCM ointment for topical application. It has been applied for prevention and management of CIPN clinically for more than 10 years. Previous animal experiments and clinical studies had manifested the availability of WLT. However, due to the unclear mechanisms of WLT, further transformation has been restricted. To investigate the therapeutic mechanisms of WLT, a metabolomic method on the basis of UPLC- MS was developed in this study. Multivariate analysis techniques, such as principal component analysis (PCA) and partial least squares discriminate analysis (PLS-DA), were applied to observe the disturbance in the metabolic state of the paclitaxel-induced peripheral neuropathy (PIPN) rat model, as well as the recovering tendency of WLT treatment. A total of 19 significant variations associated with PIPN were identified as biomarkers. Results of pathway analysis indicated that the metabolic disturbance of pathways of linoleic acid (LA) metabolism and glycerophospholipid metabolism. WLT attenuated mechanical allodynia and rebalanced the metabolic disturbances of PIPN by primarily regulating LA and glycerophospholipid metabolism pathway. Further molecular docking analysis showed some ingredients of WLT, such as hydroxysafflor yellow A (HSYA), icariin, epimedin B and 4-dihydroxybenzoic acid (DHBA), had high affinity to plenty of proteins within these two pathways.

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Section: Discussionmentioning

confidence: 99%

Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways

Deng

et al. 2018

Front. Pharmacol.

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“…LPS is a well-known inducer of inflammation in macrophages, cancer cells, and epithelial cells, although the inflammatory gene expression varies with cell type. Increasing evidence showed that NF-κB and AP-1 are necessary for LPS-induced inflammation [ 31 ]. Furthermore, p65 and c-Jun are commonly used as markers of the activation of the AP-1 and NF-κB pathways.…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene and 4′-Methoxyresveratrol Inhibited Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages

et al. 2018

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Pterostilbene (Pte) and 4′-Methoxyresveratrol (4MR) are methylated derivatives of resveratrol. We investigated the anti-inflammatory effect of Pte and 4MR in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. Both Pte and 4MR significantly reduced LPS-induced nitric oxide release by inhibiting the inducible nitric oxide synthase mRNA expression. Moreover, both of them inhibited LPS-induced mRNA expression of inflammatory cytokines including monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6 and IL-1β, and tumor necrosis factor α (TNF-α), and attenuated LPS-induced nuclear factor-κB (NF-κB) activation by decreasing p65 phosphorylation. In addition, 4MR but not Pte inhibited LPS-induced the activator protein (AP)-1 pathway in RAW 264.7 macrophages. Further study suggested that Pte had an inhibitory effect on extracellular regulated protein kinases (ERK) and p38 activation, but not on c-Jun N-terminal kinase (JNK), while 4MR had an inhibitory effect on JNK and p38 activation, but not on ERK. Taken together, our data suggested that Pte induced anti-inflammatory activity by blocking mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways, while 4MR showed anti-inflammatory activity through suppression of MAPK, AP-1, and NF-κB signaling pathways in LPS-treated RAW 264.7 macrophages.

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“…Substances contained in the plant limited the proliferation of Escherichia, Pseudomonas, Salmonella, and Staphylococcus [55]. Moschamine obtained from C. tinctorius seeds has anti-inflammatory effect: it inhibits prostaglandin E2 and nitric oxide production in macrophages [56]. 7 International Journal of Food Science (AGEs) and methylglyoxal in the organism's cells, which have toxic effect on cells (apoptosis), tissues (accelerated aging), and organs (destruction).…”

Section: Antioxidative Antiseptic and Anti-inflammatory Effectmentioning

confidence: 99%

Bioactive Substances in Safflower Flowers and Their Applicability in Medicine and Health-Promoting Foods

Adamska

Biernacka

2021

International Journal of Food Science

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Safflower flowers (Carthamus tinctorius) contain many natural substances with a wide range of economic uses. The most famous dye isolated from flower petals is hydroxysafflor A (HSYA), which has antibacterial, anti-inflammatory, and antioxidant properties. This review is aimed at updating the state of knowledge about their applicability in oncology, pulmonology, cardiology, gynecology, dermatology, gastrology, immunology, and suitability in the treatment of obesity and diabetes and its consequences with information published mainly in 2018-2020. They were also effective in treating obesity and diabetes and its consequences. The issues related to the possibilities of using HSYA in the production of health-promoting food were also analyzed.

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Inhibitory effect of moschamine isolated from Carthamus tinctorius on LPS-induced inflammatory mediators via AP-1 and STAT1/3 inactivation in RAW 264.7 macrophages

Cited by 21 publications

References 25 publications

Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways

Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways

Pterostilbene and 4′-Methoxyresveratrol Inhibited Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages

Bioactive Substances in Safflower Flowers and Their Applicability in Medicine and Health-Promoting Foods

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