Inhibitory effect of Monascus purpureus pigment extracts against fungi and mechanism of action

Majhi, Swapna; Dhale, Mohan Appasaheb; Puttananjaiah, Mohankumari Honganoor

doi:10.3389/fsufs.2023.1100961

Cited by 1 publication

(2 citation statements)

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“…It was hypothesized that MPs accumulate on the surface of bacterial cells and interfere with the membrane transport [ 11 , 16 ] and recently it was demonstrated that in fungi they disrupt membrane potential [ 19 ]. Thus, it seems that MPs interact mainly with cell surfaces what seems to be a benefit for the potential photosensitizing activity of MEs.…”

Section: Discussionmentioning

confidence: 99%

“…To summarize the current knowledge in this field, it seems that yellow MPs exhibit selective antimicrobial activity against Gram-positive bacteria [ 10 , 14 ], orange MPs display antimicrobial activity against both Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus [ 11 , 12 ], Escherichia coli [ 15 ] and Bacillus subtilis [ 10 ] and red MPs and their amino acid derivatives are effective against bacteria, as well as against some filamentous fungi [ 11 , 16 – 18 ]. It seems that the main effect of MPs can be expected on the surface of microbial cells, where they interact with the cell envelopes [ 12 ], disrupt membrane potential [ 19 ], prevent transport phenomena and oxygen access to the cells [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Screening Antibacterial Photodynamic Effect of Monascus Red Yeast Rice (Hong-Qu) and Mycelium Extracts

Husakova,

Orlandi,

Bolognese

et al. 2024

Curr Microbiol

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The fungus Monascus is a well-known source of secondary metabolites with interesting pharmaceutical and nutraceutical applications. In particular, Monascus pigments possess a wide range of biological activities (e.g. antimicrobial, antioxidant, anti-inflammatory or antitumoral). To broaden the scope of their possible application, this study focused on testing Monascus pigment extracts as potential photosensitizing agents efficient in antimicrobial photodynamic therapy (aPDT) against bacteria. For this purpose, eight different extracts of secondary metabolites from the liquid- and solid-state fermentation of Monascus purpureus DBM 4360 and Monascus sp. DBM 4361 were tested against Gram-positive and Gram-negative model bacteria, Bacillus subtilis and Escherichia coli and further screened for ESKAPE pathogens, Staphylococcus aureus and Pseudomonas aeruginosa. To the bacterial culture, increasing concentration of extracts was added and it was found that all extracts showed varying antimicrobial activity against Gram-positive bacteria in dark, which was further increased after irradiation. Gram-negative bacteria were tolerant to the extracts’ exposure in the dark but sensitivity to almost all extracts that occurred after irradiation. The Monascus sp. DBM 4361 extracts seemed to be the best potential candidate for aPDT against Gram-positive bacteria, being efficient at low doses, i.e. the lowest total concentration of Monascus pigments exhibiting aPDT effect was 3.92 ± 1.36 mg/L for E. coli. Our results indicate that Monascus spp., forming monascuspiloin as the major yellow pigment and not-forming mycotoxin citrinin, is a promising source of antimicrobials and photoantimicrobials.

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Section: Discussionmentioning

confidence: 99%