Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunction

Ouyang, Haichun; Zhong, Jian‐Jiang; Lu, Jianhua; Zhong, Yuan‐Lin; Hu, Yunzhao; Tan, Ying

doi:10.1007/s10735-019-09836-w

Cited by 22 publications

(11 citation statements)

References 54 publications

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“…The molecular mechanism involved an interplay of RHDV-induced autophagy with oxidative stress, ER stress and apoptosis [38]. A recent study illustrated that melatonin treatment attenuated viral myocarditis via sustaining cardiomyocyte viability, repressing mitochondrial dysfunction and inhibiting ER stress [39]. The rationale for using melatonin in viral diseases is supported by its capability to modulate UPR during viral infection due to its immune enhancing actions, anti-inflammatory and antioxidant properties.…”

Section: Viral Infection Melatonin and Er Stressmentioning

confidence: 99%

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

et al. 2020

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Viral Infection Melatonin and Er Stressmentioning

confidence: 99%

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

et al. 2020

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“…Melatonin also repressed ER stress and maintained mitochondrial dysfunction. Furthermore, Mst1 was upregulated by virus infection, which reduced by melatonin ( Ouyang et al, 2019 ). Sang and co-workers performed an in vivo study to investigate protective effects of melatonin on viral myocarditis and explore possible mechanisms.…”

Section: Melatonin and Viral Infections: Cellular Signaling And Theramentioning

confidence: 99%

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

et al. 2020

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“…Inflammation largely belongs to the innate immune response. Meanwhile, several studies have reported antiviral and antibacterial activities of melatonin in animals and in plants (50)(51)(52)(53). These reports are challenging with regard to the questions of whether and under which conditions melatonin enhances or suppresses the innate immunity in organisms.…”

Section: Introductionmentioning

confidence: 99%

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Tan¹,

Hardeland²

2020

Melatonin Res.

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The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. Patients are vulnerable and mortality usually occurs during this window period. To control the innate immune response and reduce the inflammation during this period will increase the tolerance of patients and lowers the mortality in the deadly virus infection. Melatonin is a molecule that displays respective properties, since it downregulates the overreaction of the innate immune response and overshooting inflammation, but also promotes the adaptive immune activity. Many studies have reported the beneficial effects of melatonin on deadly virus infections in different animal models and its therapeutic efficacy in septic shock patients. Furthermore, melatonin has a great safety margin without serious adverse effects. We suggest the use of melatonin as an adjunctive or even regular therapy for deadly viral diseases, especially if no efficient direct anti-viral treatment is available.

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Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunction

Cited by 22 publications

References 54 publications

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

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