Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K–Akt pathways

Lee, Wei Jiunn; Wu, Lan; Chen, Wen Kang; Wang, Chau Jong; Tseng, Tsui Hwa

doi:10.1016/j.cbi.2006.01.002

Cited by 113 publications

(81 citation statements)

References 34 publications

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“…Activation of PI3K-Akt and ERK pathways has been suggested to be critical for cell motility stimulated by HGF [30,31,37] …”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that HGF induces cell invasion of HepG2 cells via the ERK pathway and phosphatidylinositol 3-kinase (PI3K)-Akt pathway [30,31]. VPA (2 mM), however, did not show any significant effect on phosphorylation of ERK and Akt or nuclear translocation of phosphorylated ERK in the cells treated for 15, 30 and 60 min with HGF (10 ng/ml) (data not shown).…”

Section: Hgf-induced Invasion Of Hepg2 Cells (Data Not Shown)mentioning

confidence: 92%

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Inhibition of tumor–stromal interaction through HGF/Met signaling by valproic acid

Matsumoto

Motoki

Kubota

et al. 2008

Biochemical and Biophysical Research Communications

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Hepatocyte growth factor (HGF), which is produced by surrounding stromal cells, including fibroblasts and endothelial cells, has been shown to be a significant factor responsible for cancer cell invasion mediated by tumor-stromal interactions. We found in this study that the anti-tumor agent valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, strongly inhibited tumor-stromal interaction. VPA inhibited HGF production in fibroblasts induced by epidermal growth factor (EGF), platelet-derived growth factor, basic fibroblast growth factor, phorbol 12-myristate 13-acetate (PMA) and prostaglandin E 2 without any appreciable cytotoxic effect.

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“…Activation of PI3K-Akt and ERK pathways has been suggested to be critical for cell motility stimulated by HGF [30,31,37] …”

Section: Discussionmentioning

confidence: 99%

Section: Hgf-induced Invasion Of Hepg2 Cells (Data Not Shown)mentioning

confidence: 92%

Inhibition of tumor–stromal interaction through HGF/Met signaling by valproic acid

Matsumoto

Motoki

Kubota

et al. 2008

Biochemical and Biophysical Research Communications

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“…The ability of cancers to metastasize is directly associated with cell adhesion and invasion (Lee et al 2006). Adhesive ability of metastatic tumor cells is a critical factor in extravasations and formation of new tumor foci.…”

Section: Pl Suppresses Adhesive and Invasive Behavior Of Hepg2 Cellsmentioning

confidence: 99%

Polysaccharides from Phellinus linteus inhibit cell growth and invasion and induce apoptosis in HepG2 human hepatocellular carcinoma cells

et al. 2012

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It has been demonstrated that the medicinal mushroom Phellinus linteus (PL), which consists mainly of polysaccharides, possesses antitumor and immunomodulatory properties in vivo and in vitro. The mechanism, however, by which PL inhibits growth and invasive behavior of HepG2 cells remains poorly understood. Here we demonstrated that PL inhibited proliferation and colony formation of HepG2 and that the growth inhibition of HepG2 cells was mediated by S-phase cell cycle arrest. PL also markedly inhibited cancer cell adhesion and invasion of the extracellular matrix. Additionally, we demonstrated that PL-induced apoptosis was associated with a reduction in B-cell lymphoma 2 levels and an increase in the release of cytochrome c. These results suggest that PL exerts a direct antitumor effect by initiating apoptosis and cell cycle blockade in HepG2 cells.

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“…The anticancer effect of Lu also is associated with inducing apoptosis, which involves redox regulation, DNA damage, and protein kinases in inhibiting the proliferation of cancer cells and suppressing metastasis and angiogenesis. 6,[10][11][12][13][14][15][16][17] Moreover, Lu has cytotoxicity in cancer cells or immortalized cells, but not in normal cells, meaning that it has fewer side effects when used in treating cancer. 8,12,18 Yet Lu has some drawbacks, such as poor water solubility (,2 × 10 −2 µmol/mL), 19 low oral absorption, 20 and bioavailability (30.4% in rats), 21 which limit its clinical application.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) micelles for the solubilization and in vivo delivery of luteolin

Qiu¹,

Gao²,

Wang³

et al. 2013

IJN

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Luteolin (Lu) is one of the flavonoids with anticancer activity, but its poor water solubility limits its use clinically. In this work, we used monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles to encapsulate Lu by a self-assembly method, creating a water-soluble Lu/MPEG-PCL micelle. These micelles had a mean particle size of 38.6 ± 0.6 nm (polydispersity index = 0.16 ± 0.02), encapsulation efficiency of 98.32% ± 1.12%, and drug loading of 3.93% ± 0.25%. Lu/MPEG-PCL micelles could slowly release Lu in vitro. Encapsulation of Lu in MPEG-PCL micelles improved the half-life (t ½ ; 152.25 ± 49.92 versus [vs] 7.16 ± 1.23 minutes, P = 0.007), area under the curve (0-t) (2914.05 ± 445.17 vs 502.65 ± 140.12 mg/L/minute, P = 0.001), area under the curve (0-∞) (2989.03 ± 433.22 vs 503.81 ± 141.41 mg/L/minute, P = 0.001), and peak concentration (92.70 ± 11.61 vs 38.98 ± 7.73 mg/L, P = 0.003) of Lu when the drug was intravenously administered at a dose of 30 mg/kg in rats. Also, Lu/MPEG-PCL micelles maintained the cytotoxicity of Lu on 4T1 breast cancer cells (IC50 = 6.4 ± 2.30 µg/mL) and C-26 colon carcinoma cells (IC50 = 12.62 ± 2.17 µg/mL) in vitro. These data suggested that encapsulation of Lu into MPEG-PCL micelles created an aqueous formulation of Lu with potential anticancer effect.

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Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K–Akt pathways

Cited by 113 publications

References 34 publications

Inhibition of tumor–stromal interaction through HGF/Met signaling by valproic acid

Inhibition of tumor–stromal interaction through HGF/Met signaling by valproic acid

Polysaccharides from Phellinus linteus inhibit cell growth and invasion and induce apoptosis in HepG2 human hepatocellular carcinoma cells

Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) micelles for the solubilization and in vivo delivery of luteolin

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Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K–Akt pathways

Cited by 113 publications

References 34 publications

Inhibition of tumor–stromal interaction through HGF/Met signaling by valproic acid

Inhibition of tumor–stromal interaction through HGF/Met signaling by valproic acid

Polysaccharides from Phellinus linteus inhibit cell growth and invasion and induce apoptosis in HepG2 human hepatocellular carcinoma cells

Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(&epsilon;-caprolactone) micelles for the solubilization and in vivo delivery of luteolin

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Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) micelles for the solubilization and in vivo delivery of luteolin