Inhibitory Effect of Lentivirus-Mediated Gag-Caspase-8 on the Growth of HER-2 Overexpressing Primary Human Breast Cancer Cells

Wang, Min; Li, Xiping; Xie, Wenli; Zhong, Li; Li, Yu; Chen, Xiaoqiong; Yang, Mei; Qi, Ling; Zhang, Zhenda; Liu, Linjian; Tang, Dongdong

doi:10.1089/cbr.2021.0124

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Vsv-g-pseudotyped Lvs In Cancer Gene Therapy1

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2023

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“…Moreover, VSV-G pseudotyped LVs efficiently deliver CASP8 into breast cancer cells, leading to massive cell apoptosis and death and suppressed tumor growth of breast cancer model. 146 , 147 These LVs also cause significant growth inhibition of human renal cell carcinoma (RCC) cells by transfecting tumor suppressor genes p53 , p16 , and PTEN simultaneously. 148 Thus, the transfection of tumor suppressor genes mediated by VSV-G pseudotyped LVs exerts promising anti-tumor effects on human breast cancer and RCC, providing a reference for gene therapy of these cancers.…”

Section: Vsv-g-pseudotyped Lvs In Cancer Gene Therapymentioning

confidence: 99%