Inhibitory effect of <i><scp>Z</scp>ingiber cassumunar</i> extracts on lipopolysaccharide‐induced cyclooxygenase‐2 and matrix metalloproteinase expression in human gingival fibroblasts

Koontongkaew, Sittichai; Meesuk, Ladda; Aupaphong, Visakha; Ayudhaya, T. Dechatiwongse Na; Poachanukoon, Orapan

doi:10.1111/jre.12033

Cited by 22 publications

(18 citation statements)

References 52 publications

(62 reference statements)

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“…34 Although the underlying mechanism of the action of Phlai and compound D on PMAmediated MMP-9 activation in airway epithelial cells is not clear at present, our previous work has shown that crude Phlai extract suppresses MMP-2 via the inhibition of ERK activation in LPSstimulated human gingival fibroblasts. 35 Therefore, it is conceivable that Phlai and compound D may suppress PMA-induced MMP-9 production in NCI-H292 cells through the inhibition of PAR-2 and ERK activation. In conclusion, our results show that crude phlai extract and its constituent compound D inhibit the cleavage of pro-MMP-9 and MMP-9 production in PMA-induced airway epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Zingiber cassumunar ROXb. and its active constituent inhibit MMP-9 direct activation by house dust mite allergens and MMP-9 expression in PMA-stimulated human airway epithelial cells

2014

Asian Pac J Allergy Immunol

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Section: Discussionmentioning

confidence: 99%

Zingiber cassumunar ROXb. and its active constituent inhibit MMP-9 direct activation by house dust mite allergens and MMP-9 expression in PMA-stimulated human airway epithelial cells

2014

Asian Pac J Allergy Immunol

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“…Terpinen-4-ol merupakan salah satu golongan terpenoid yang merupakan konstituen utama yang terkandung di dalam rimpang bangle (Zingiber cassumunar) dengan kandungan mencapai 30-35% dari keseluruhan senyawa yang terkandung di dalam rimpang bangle (Bhuiyan, 2018). Hasil uji in vitro menunjukkan bahwa ekstrak etanol Zingiber cassumunar dapat menghambat COX dan produksi matriks metalloproteinase MMP-2 dengan memblokir jalur sinyal proinflamasi yang melibatkan ERK 1/2, JNK, dan p38 pada jalur MAPK (Koontongkaew et al, 2013).…”

Section: Pendahuluanunclassified

Molecular Docking Terpinen-4-Ol Sebagai Antiinflamasi Pada Aterosklerosis Secara in Silico

Susanti

Laksmiani

Noviyanti

et al. 2019

JCHEM

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Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Mitogen Activated Protein Kinase (MAPK) pathway involving ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, as well as the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen-4-ol is constituent found in the bangle rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins as anti-inflammatory in atherosclerosis performed using molecular docking method. The study was conducted exploratively with several steps such as preparation and optimization of terpinen-4-ol structure, preparation of 3D ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, validation method of molecular docking, and docking terpinen-4-ol in these proteins. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and proteins. The smaller value of binding energy terpinen-4-ol with target proteins showed the complex that form more stable. The result showed that terpinen-4-ol and has activity in inhibiting the inflammatory process because it is able to disturb ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins with respective bond energy values -5,12; -5,24; -5,08; -5,88; and -4,99 Kcal/mol. The molecular mechanism in inhibiting the activity of ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins is through the formation of hydrogen bonds in these proteins. These results show that terpinen-4-ol have the potential to inhibit inflammatory process and the formation of atherosclerotic plaque can be obstructed. Keywords : atherosclerosis, terpinen-4-ol, molecular docking, in silico

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“…,5΄΄΄-trimethoxy-sty ryl]cyclohex-1-ene (compound C) and DMPBD reduced PGE 2 and COX-2 expression in dental pulp inflammation Koontongkaew et al, 2013). In addition, curcumin, which was found as a minor compound in Z. cassumunar, has an ability to suppress the expression of COX-2 (Surh and Kundu, 2007).…”

Section: Chemical Constituents and Anti-inflammatory Activity Of Prasmentioning

confidence: 99%

Prasaplai: An essential Thai traditional formulation for primary dysmenorrhea treatment

Tangyuenyongwatana¹,

Gritsanapan²

2014

TANG [HUMANITAS MEDICINE]

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Affecting more than half of menstruating women, dysmenorrhea is a cramp which causes abdominal or lower back pain just before or during a menstruation. In western medicine, non-steroidal antiinflammatory drugs (NSAIDs) are normally used to treat primary dysmenorrheal symptoms. Despite their rapidity in relieving pain, NSAIDs have many serious side effects on the liver, kidney, and gastrointestinal tract. Thai traditional medicines comprise many preparations for treating dysmenorrhea, especially Prasaplai preparation which has been listed in the Thai traditional common household drug list since 2006. The use of Prasaplai was originated about 100 years ago and is still being used in the present time to treat dysmenorrhea. This review focuses on the history of the preparation, active ingredients, and biological activities especially on cyclooxygenase inhibitor, artifacts occurred in the preparation, quantitative analysis, and clinical trial of Prasaplai formulation.

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Inhibitory effect of Zingiber cassumunar extracts on lipopolysaccharide‐induced cyclooxygenase‐2 and matrix metalloproteinase expression in human gingival fibroblasts

Abstract: Our results indicate that Z. cassumunar extracts inhibit COX-2 and MMP-2 production by LPS-activated human gingival fibroblasts through blocking the proinflammatory signaling pathway involving ERK1/2, JNK and p38.

Cited by 22 publications

References 52 publications

Zingiber cassumunar ROXb. and its active constituent inhibit MMP-9 direct activation by house dust mite allergens and MMP-9 expression in PMA-stimulated human airway epithelial cells

Zingiber cassumunar ROXb. and its active constituent inhibit MMP-9 direct activation by house dust mite allergens and MMP-9 expression in PMA-stimulated human airway epithelial cells

Molecular Docking Terpinen-4-Ol Sebagai Antiinflamasi Pada Aterosklerosis Secara in Silico

Prasaplai: An essential Thai traditional formulation for primary dysmenorrhea treatment

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