Inhibitory effect of histamine on axonal transport in cultured mouse dorsal root ganglion neurons

Pharmacological evidence that histamine H3 receptors inhibit the vasodepressor responses by selective stimulation of the rat perivascular sensory CGRPergic outflow

“…On this basis, the sensory-inhibitory histamine H 3 receptors in our experimental model in pithed rats could be located on capsaicin-sensitive sensory C perivascular nerves. Consistent with this speculation, studies in cultured mouse dorsal root ganglion neurons have shown that histamine inhibits axonal transport by activation of histamine H 3 receptors (Amano et al, 2001).…”

Long lasting recruitment of immune cells and altered epi-perineurial thickness in focal nerve inflammation induced by complete Freund's adjuvant

“…Axoplasmic transport is slowed during inflammation (Amano et al, 2001; Armstrong et al, 2004), but by unknown factors. In-vitro, CFA nerve inflammation caused a histamine-dependent reduction in axoplasmic flow.…”

Resolution of Inflammation-Induced Axonal Mechanical Sensitivity and Conduction Slowing in C-Fiber Nociceptors

“…First, nerve inflammation and histamine can cause disruption of axonal transport. 1,2 There is evidence to suggest that the cellular components necessary for normal mechanosensitivity are conveyed by fast axonal transport. 26 The disruption of axonal transport at the treatment site by inflammation may result in the localized accumulation and insertion of mechanically sensitive ion channels into an otherwise intact axon.…”