Inhibitory Effect of High Dietary Zinc on Copper Absorption in Rats

Ogiso, Taketo; Moriyama, Kazuo; Sasaki, Sanae; Ishimura, Yoshiko; Minato, Atsushi

doi:10.1248/cpb.22.55

Cited by 50 publications

(11 citation statements)

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“…Sahin et al [30] have shown decreased levels of Cu and Fe in brain tissue and increase in BBB permeability in the repeated seizures group. It has been shown that taking large doses of supplemental Zn over extended periods of time has shown to be associated with Cu deficiency [31]. These findings are parallel with our results.…”

Section: Discussionsupporting

confidence: 92%

The Effects of Zinc Treatment on the Blood–Brain Barrier Permeability and Brain Element Levels During Convulsions

Yorulmaz

Seker

Demir

et al. 2012

Biol Trace Elem Res

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We evaluated the effect of zinc treatment on the blood–brain barrier (BBB) permeability and the levels of zinc (Zn), natrium (Na), magnesium (Mg), and copper (Cu) in the brain tissue during epileptic seizures. The Wistar albino rats were divided into four groups, each as follows: (1) control group, (2) pentylenetetrazole (PTZ) group: rats treated with PTZ to induce seizures, (3) Zn group: rats treated with ZnCl2 added to drinking water for 2 months, and (4) Zn + PTZ group. The brains were divided into left, right hemispheres, and cerebellum + brain stem regions. Evans blue was used as BBB tracer. Element concentrations were analyzed by inductively coupled plasma optical emission spectroscopy. The BBB permeability has been found to be increased in all experimental groups (p < 0.05). Zn concentrations in all brain regions in Zn-supplemented groups (p < 0.05) showed an increase. BBB permeability and Zn level in cerebellum + brain stem region were significantly high compared to cerebral hemispheres (p < 0.05). In all experimental groups, Cu concentration decreased, whereas Na concentrations showed an increase (p < 0.05). Mg content in all the brain regions decreased in the Zn group and Zn + PTZ groups compared to other groups (p < 0.001). We also found that all elements’ levels showed hemispheric differences in all groups. During convulsions, Zn treatment did not show any protective effect on BBB permeability. Chronic Zn treatment decreased Mg and Cu concentration and increased Na levels in the brain tissue. Our results indicated that Zn treatment showed proconvulsant activity and increased BBB permeability, possibly changing prooxidant/antioxidant balance and neuronal excitability during seizures.

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Section: Discussionsupporting

confidence: 92%

The Effects of Zinc Treatment on the Blood–Brain Barrier Permeability and Brain Element Levels During Convulsions

Yorulmaz

Seker

Demir

et al. 2012

Biol Trace Elem Res

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“…Moreover, the highest dose of zinc provoked significantly lower copper concentration in erythrocytes and higher copper concentration in the liver. Adverse effects on copper homeostasis were also equally marked as the zinc treatment dose increased up to 1 mg/kg, in agreement with previous studies that have shown that the copper status of rats was compromised when they consumed a high zinc diet [26,27].…”

Section: Discussionsupporting

confidence: 91%

Toxic Effects of Iterative Intraperitoneal Administration of Zinc Gluconate in Rats

Andriollo-Sanchez¹,

Claeyssen²,

Arnaud³

et al. 2008

Basic Clin Pharma Tox

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Although zinc is an essential trace element involved in many physiological functions, toxicological data concerning acute exposure are scarce. The aim of our study was to determine the maximal iterative dose of zinc that can be administrated in rats without any adverse effect. Saline (control group) or zinc gluconate at 1, 2 or 4 mg/kg were intraperitoneally injected in animals daily during 7 days. The tolerance of zinc treatments was evaluated by the observation of clinical symptoms, haematological parameters and biochemistry, in relation to the zinc and copper levels in blood, liver, pancreas and faeces. We found no serious adverse effect within 1 week in rats injected intraperitoneally with 1 or 2 mg/kg/day of zinc gluconate, which tends to indicate that those doses could be useful in future therapeutic research. In contrast, the therapeutic treatment of adult rats with repeated intraperitoneal injections of a 4 mg/kg/day zinc dose should be cancelled, due to the occurrence of clinical adverse effects within a few days, as intraperitoneal local intolerance or major growth underdevelopment.

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“…2, 3 and 4) caused by Cu deficiency [43,44], which is in conformity with previous findings that reported an extensive depletion of pancreatic acinar tissue in Cu-deficient rats [45][46][47]. This Cu deficiency most likely leads to perturbations of inter and intracellular milieu, leading to activation of apoptosis-associated genes and endonuclease activation [18] as observed in rat and ducklings under Zn toxicosis [13,48]. Cu deficiency also affects the seleno-protein regulation independently leading to Se deficiency [49].…”

Section: Discussionsupporting

confidence: 86%

Attenuation of Zn-Induced Acute Pancreatitis in Wistar Rat Fed on Cu- and Mg- Enriched Modified Poultry % MathType!Translator!2!1!AMS LaTeX.tdl!TeX -- AMS-LaTeX!% MathType!MTEF!2!1!+-% feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaacbeGaa8xrai% aa-DgacaWFNbWaaWbaaSqabeaaiiqacqGFOoqwaaaaaa!3

Taneja

Mandal

2008

Biol Trace Elem Res

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Zinc (Zn) consumption has increased in many populations either due to the increased intake of Zn-fortified foods as in the USA or in agricultural food stuffs as in some Indian states during the last decade. Its excessive intake has been reported to induce acute pancreatitis (AP) in many studies due to increase in oxidative stress that was further reported to cause Cu and Mg deficiencies. This led us to design a modified poultry egg (ME(Psi)) enriched with Cu and Mg along with other antioxidants, and its efficacy on Zn-induced AP was studied in male Wistar rats. In one set, the rats were fed on equacaloric semi-synthetic basal diet containing 20 mg Zn/kg diet (control, group I), and Zn-induced AP-I diet and AP-II diet containing 40 and 80 mg Zn/kg diet (groups II and III) for 180 days, respectively. In another set, the rats were initially fed on Zn-induced AP-I and AP-II diets for 90 days and then shifted to ME(Psi)-mixed Zn-induced AP-I and AP-II diets in groups IIME and IIIME for another 90 days. At the end of the experiment, data displayed increased serum and urinary Zn, Cu, and Mg levels in groups II and III rats, which were reduced and approached closer to control group I after ME(Psi) feeding in groups IIME and IIIME rats. Transmission electron microscopic studies of acinar cells revealed progressive dilation, vesicularization, and degeneration of endoplasmic reticulum (ER), and decrease in zymogen granules (ZG) in groups II and III rats in contrast to their curvilinear or concentric long parallel running cisternal profile of ER in control group I. The treatment of ME(Psi) helped in the restoration of the ER profile and ZG number, approaching closer to the control group I. The degree of recovery was dependent upon the degree of toxicity caused by the amount of Zn given in the diet. The results of this study suggest that ME(Psi)-mixed diet can protect the acinar cells from the deleterious effects of Zn by decreasing the oxidative stress.

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Inhibitory Effect of High Dietary Zinc on Copper Absorption in Rats

Cited by 50 publications

References 0 publications

The Effects of Zinc Treatment on the Blood–Brain Barrier Permeability and Brain Element Levels During Convulsions

The Effects of Zinc Treatment on the Blood–Brain Barrier Permeability and Brain Element Levels During Convulsions

Toxic Effects of Iterative Intraperitoneal Administration of Zinc Gluconate in Rats

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