Inhibitory effect of glycosides like saponin from soybean on the infectivity of HIV in vitro

Antiviral Activity of a Hot Water Extract of Black Soybean against a Human Respiratory Illness Virus

“…The antiviral activity of soyasaponin against the herpes simplex virus, human immunodeˆciency virus, human cytomegalovirus, and FluV A has been reported. [8][9][10][11] Since it has been reported that soyasaponin was recovered in 70z aqueous ethanol, we presumed that the antiviral activity of the hot-water extract of black soybean against Ad1 would have come from compound(s) other than soyasaponin. As shown in Fig.…”

“…Since acute respiratory tract diseases are mainly caused by infection from viruses such as the adenovirus, in‰uenza virus, and coxsackievirus, 7) we have presumed that the pharmacological eŠect of the black soybean extract on the disease might be due to antiviral activity. Concerning the antiviral activity of soybean, it has been reported that soyasaponin from the common yellowish soybean inhibited the replication of the herpes simplex virus, 8,9) human immuno-deˆciency virus (HIV), 8,10,11) cytomegalovirus, 8) and in‰uenza virus. 8) However, the speciˆc antiviral activity of the black soybean extract against respiratory illness viruses has not been previously investigated.…”

Isolation, purification and partial characterization of a glycoside from the Jamaican ball moss plant (<i>Tillandsia recurvata</i> L.)

“…The basic structure of soyasaponins is an oleanene-type triterpenoidaglycone with one or more polysaccharide chains attached, resulting in the amphiphilic nature of the molecules. Soyasaponins have been shown to have a variety of health-promoting properties including anti-viral activities [20,21] and anti-carcinogenic [22,23], plasma cholesterol lowering [24,25], and hepatoprotective effects [26,27].…”

Soy and Soy-Based Foods: Role in Health and Nutrition

“…In addition, they have been employed as immunological adjuvants in vaccine formulations due to their immune enhancing properties (Kensil et al 2004). For instance, saponins appear to inhibit the infectivity of the AIDS virus (Nakashima et al 1989;Vlietinck et al 1998) and the herpes simplex virus type 1 (Hayashi et al 1997). Soyasaponins are reported to be hepatoprotective (Kinjo et al 2003) and have also shown a preventive effect on the growth of human colon cancer cells (Tsai et al 2010).…”