Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage Inflammatory Protein‐2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells

Sakai, Shinya; Kawamata, Hiroshi; Kogure, Toshiaki; Mantani, Naoki; Terasawa, Katsutoshi; Umatake, Miho; Ochiai, Hiroshi

doi:10.1080/09629359990513

Cited by 112 publications

(75 citation statements)

References 14 publications

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“…The progressive increase of MCP-1, MIP-1␤, and MIP-2 gene expressions at early time points in PBS control mice is consistent with previous reports of chemokine responses in RSV-infected human and murine cells in vitro (5,17,22,33). It also concurs with a mainly T-cell recruitment to the lungs during primary RSV infection (23,39).…”

Section: Discussionsupporting

confidence: 79%

Differential Histopathology and Chemokine Gene Expression in Lung Tissues following Respiratory Syncytial Virus (RSV) Challenge of Formalin-Inactivated RSV- or BBG2Na-Immunized Mice

Power

Huss

Michaud

et al. 2001

J Virol

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A BALB/c mouse model of enhanced pulmonary pathology following vaccination with formalin-inactivated alum-adsorbed respiratory syncytial virus (FI-RSV) and live RSV challenge was used to determine the type and kinetics of histopathologic lesions induced and chemokine gene expression profiles in lung tissues. These data were compared and contrasted with data generated following primary and/or secondary RSV infection or RSV challenge following vaccination with a promising subunit vaccine, BBG2Na. Severe peribronchiolitis and perivascularitis coupled with alveolitis and interstitial inflammation were the hallmarks of lesions in the lungs of FI-RSV-primed mice, with peak histopathology evident on days 5 and 9. In contrast, primary RSV infection resulted in no discernible lesions, while challenge of RSV-primed mice resulted in rare but mild peribronchiolitis and perivascularitis, with no evidence of alveolitis or interstitial inflammation. Importantly, mice vaccinated with a broad dose range ( Respiratory syncytial virus (RSV), a Pneumovirus of the family Paramyxoviridae, is a major respiratory pathogen. Infection often results in acute bronchiolitis or pneumonia in infants and young children and can result in persistently abnormal pulmonary function throughout childhood. In addition, adults become reinfected despite enhanced serum antibody responses. Consequently, development of an RSV vaccine is considered a World Health Organization priority. The occurrence of a severe pulmonary disease, characterized by the presence of abnormally numerous inflammatory cells (18), after subsequent natural infection in children given a formalin-inactivated RSV (FI-RSV) vaccine has greatly interfered in the development of a successful and safe RSV vaccine (21).We explored a subunit approach to the development of a RSV vaccine and have described the construction and expression of a RSV (Long strain) G envelope glycoprotein fragment as part of a chimeric protein in Escherichia coli (20,25). The polypeptide of amino acids 130 to 230 of the G protein (G2Na) is fused to BB, the albumin-binding domain of streptococcal protein G, producing BBG2Na. The immune responses induced by BBG2Na demonstrate a potent lung protective efficacy against RSV challenge in both mouse and cotton rat models of RSV infection (25). Importantly, this potent protective efficacy was maintained irrespective of whether BBG2Na was administered intraperitoneally (i.p.), intramuscularly (i.m.) or subcutaneously (s.c.) (15). The G2Na fragment contains at least five murine B-cell protectopes, one of which incorporates a stretch of amino acid residues that are completely conserved among all known RSV subgroup A and B human isolates (9) and all of which overlap with peptide reactivities in human RSV convalescent sera (24). Furthermore, we recently reported that immunizations with BBG2Na do not induce evidence of pulmonary inflammation upon RSV challenge, as demonstrated by the absence of aberrant and massive lung infiltration of macrophages, eosinophils, and T cells (23). ...

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Section: Discussionsupporting

confidence: 79%

Differential Histopathology and Chemokine Gene Expression in Lung Tissues following Respiratory Syncytial Virus (RSV) Challenge of Formalin-Inactivated RSV- or BBG2Na-Immunized Mice

Power

Huss

Michaud

et al. 2001

J Virol

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“…If so, then, what is the possible mechanism for the selective inhibition of TNF-α-induced expression of VCAM-1 in HUVEC by genipin? Given PPAR-γ activators can decrease expression of adhesion molecules in activated human endothelial cells [6,14,15] and PPAR-γ is expressed in vascular cells [16], we asked whether genipin induces PPAR-γ in HUVEC. We found that genipin up-regulated PPAR-γ expression in HUVEC by a concentration-and time-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells

Hwa¹,

Mun

Kim

et al. 2011

Korean J Physiol Pharmacol

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“…Ferulic acid has been shown to be among the main phenolic acids in C. heracleifolia (60) . Sakai et al (61) showed that ferulic acid and isoferulic acid could reduce macrophage inflammatory protein-2 production in a dose-dependent manner in RAW264 . 7 cells.…”

Section: Potential Health Benefits Of Phenolic Component Of Brewers' mentioning

confidence: 99%

“…7 cells. It was suggested that ferulic acid and isoferulic acid are responsible, at least in part, for the anti-inflammatory properties of the C. heracleifolia drug (61) . Recently published data have shown that ferulic acid and p-coumaric acid inhibited lipopolysaccharide-induced NO production and inducible NO synthase in macrophages (62) .…”

Section: Potential Health Benefits Of Phenolic Component Of Brewers' mentioning

confidence: 99%

Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review

et al. 2012

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Brewers' spent grain (BSG) is a low-value co-product of the brewing industry produced in large quantities annually. This paper reviews the existing evidence regarding the phenolic component of BSG, focusing on composition, extraction and biofunctions such as antioxidant, anti-atherogenic, anti-inflammatory and anti-carcinogenic activities. Furthermore, the incorporation of BSG in foodstuffs will be discussed, including the use of BSG as an animal feed supplement and the potential of BSG to be incorporated into foods for human consumption. BSG contains hydroxycinnamic acids including ferulic acid, p-coumaric acid and caffeic acid; which have shown bioactivity in the pure form (antioxidant, anti-inflammatory, antiatherogenic and anti-cancer). Phenolic extracts from BSG have also shown antioxidant potential, by protecting against oxidant-induced DNA damage, possibly by Fe chelation. Studies show that BSG has many benefits when used as a supplement in animal feed, such as increasing milk yield, milkfat content and in providing essential dietary amino acids. The incorporation of BSG in human foods such as cookies and ready-to-eat snacks has resulted in increased protein and fibre contents of the products, where the changes in organoleptic properties are controllable. It can be concluded that the phenolic component of BSG has potential bioactive effects, which are worth pursuing given that the inclusion of BSG into human foodstuffs is viable and beneficial.

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Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage Inflammatory Protein‐2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells

Abstract: WE in ves tigate d th e effect of ferulic acid (FA) and is oferulic acid (IFA),

Cited by 112 publications

References 14 publications

Differential Histopathology and Chemokine Gene Expression in Lung Tissues following Respiratory Syncytial Virus (RSV) Challenge of Formalin-Inactivated RSV- or BBG2Na-Immunized Mice

Differential Histopathology and Chemokine Gene Expression in Lung Tissues following Respiratory Syncytial Virus (RSV) Challenge of Formalin-Inactivated RSV- or BBG2Na-Immunized Mice

Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells

Brewers' spent grain; bioactivity of phenolic component, its role in animal nutrition and potential for incorporation in functional foods: a review

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