Inhibitory effect of extracts of hainosan (painongsan) and its constituent crude drugs on production of monocyte chemoattractant protein‐1 and interleukin‐6 in murine fibroblasts treated with Porphyromonas gingivalis
Abstract:Aim
Hainosan (painongsan), composed of Platycodon grandiflorum root (PG), Paeonia lactiflora root (PL), and Citrus aurantium immature fruit (AF), is a formula used in traditional Japanese (Kampo) and Chinese medicine to treat purulent diseases, including gingivitis. In this study, we investigated the anti‐inflammatory effects of hainosan extract (HNS) using both traditional direct and serum pharmacological techniques.
Methods
BALB/c mice were orally treated with HNS or extracts of its constituent crude drugs f… Show more
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