Inhibitory Effect of Eggs on Vitamin B12 Absorption: Description of a Simple Ovalbumin 57Co‐Vitamin B12 Absorption Test

Doscherholmen, Alfred; McMahon, Jean; Ripley, Donna

doi:10.1111/j.1365-2141.1976.tb03537.x

Cited by 71 publications

(24 citation statements)

References 35 publications

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“…Unfortunately, information on age, sex and ethnicity of the study populations was not provided for most of the studies. Serum vitamin B12 concentrations were reported to be normal in all but one study that included subjects with low serum concentrations [23], but only five studies [8,9,10,27,28,36] actually reported concentrations (137-546 pmol/l).…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

et al. 2013

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Aims: To systematically review the literature on daily losses and bioavailability of vitamin B12. These estimates could be used for deriving recommendations on vitamin B12 intake for adults and elderly. Methods: We identified publications on daily vitamin B12 losses (July 2011) and publications on the bioavailability of vitamin B12 from foods or diets (June 2010) in MEDLINE, EMBASE and the Cochrane Library. Results: A pooled analysis of five studies (52 subjects) showed that 0.13 ± 0.03% of the total body store is lost per day. Absorption of vitamin B12 ranged from 4.5 (dose of 38 µg from consumption of liver) to 83% (dose of 3.0 µg from consumption of mutton meat). Data from eight studies including 83 subjects suggested that the amount of vitamin B12 absorbed from food (A_i) increased with increasing doses of vitamin B12 (D_i) as described by the equation: ln(A_i) = 0.7694 * ln(D_i) - 0.9614. Conclusion: Daily vitamin B12 losses in apparently healthy adults and elderly probably range from 1.4 to 5.1 µg. Vitamin B12 intakes needed to compensate for these losses seem to range from 3.8 to 20.7 µg. More evidence is needed on the relationships between biochemical markers of vitamin B12 status, vitamin B12 body store and long-term health outcomes to evaluate whether current recommendations on vitamin B12 intake (1.4-3 µg) need to be changed.

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Section: Resultsmentioning

confidence: 99%

“…Furthermore, we extracted the absolute amount of vitamin B12 that was absorbed. In case this latter estimate was not reported, it was calculated as percent absorbed * ingested dose [9,27,28,29]. …”

Section: Methodsmentioning

confidence: 99%

Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

et al. 2013

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“…The annual intake of white meat increased from 30.5 to 53.9 kg per capita whilst that of beef and lamb in creased from 22 to 33.1 kg per capita between 1960 and 1980 [62], The effect of cooking is not always appreciated, although allowed for in the tables of Paul and Southgate [9]. Heat may destroy more than a quarter of the vita min in meat [63], Certain foods, notably egg white and egg yolk [64], inhibit the absorption of the vitamin but we could not make allow ance for this in our dietary assessment. More over, when calculating the amount available to the individual, the limitation to absorption by saturation of the ileal receptors also has to be considered [63].…”

Section: Discussionmentioning

confidence: 99%

Vitamin Status of Healthy Subjects in Burgundy (France)

Carvalho¹,

Guilland

Moreau

et al. 1996

Ann Nutr Metab

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A nutrition survey was conducted in Burgundy (France) with a population sample of 337 middle-aged and healthy subjects (157 males and 180 females) recruited at a health examination center in 1985-1986. The status of β-carotene, thiamin, riboflavin, folate, vitamin B₆, B₁₂, C, A, D, and E was assessed by means of 7-day food records and biochemical studies. Results were compared with two other recent nutritional surveys conducted in France: ESVITAF (control group only) and Val de Marne surveys. The dietary information collected for each subject was compared to the 1992 French Recommended Dietary Allowances (FRDA). Dietary vitamin intakes were higher in males than in females. Low vitamin intakes ( < 1/2 FRDA) were found in 5% of males and 7% of females for thiamin, in 11% of males and 28% of females for vitamin Be, in 6% of males and 3% of females for vitamin C, in 87% of males and 91% of females for vitamin D, and in 8% of males and 13% of females for vitamin E. No subject had a vitamin intake < 1/2 FRDA for riboflavin, folate, vitamins A and Bi2. ESVITAF and Val de Marne studies also show low vitamin intakes for vitamin B₆, thiamin, riboflavin, vitamins D and E. Biochemical status was examined using erythrocyte enzyme function and blood vitamin levels. The percent of subjects with deficient biochemical values was high for vitamin B₆ (15% of all males and 20% of all females), and vitamin D (13% of all males, and 15% of all females). With regard to thiamin, riboflavin, vitamin C, folate, vitamin B₁₂, vitamin A, and vitamin E, < 5 % of subjects had values in the range of major vitamin deficiency. However, in both genders, except for vitamin C and vitamin A (only for females), low values corresponding to a moderate risk of vitamin deficiency was high for most vitamins. The incidence of a severe deficient vitamin status for thiamin and riboflavin was higher in Val de Marne than in Burgundy, or ESVITAF. In Val de Marne, the probability of a moderate risk of vitamin deficiency was high for thiamin, riboflavin, vitamin B₆, vitamin A and vitamin E. Our results (as other studies performed in France and in other industrialized countries) raise the issue of the health significance of marginally deficient vitamin status.

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“…Krasinski et al 1986). Crystalline vitamin B-12 absorption is normal in most people with atrophic gastritis, because intrinsic factor is not lowered to a critical degree (Dawson et al 1984, Doscherholmen et al 1976and 1981, Jones et al 1987, King et al 1979, Suter et al 1993. It is not known how efficient the absorption of vitamin B-12 from milk or fortified bread would be in elderly subjects with atrophic gastritis; however, it has been presumed that vitamin B-12 bioavailability from a fortified cereal product would be as high as that from a dietary supplement in subjects with atrophic gastritis, because crystalline vitamin B-12 is sprayed onto such products.…”

Section: Cyanocobalaminmentioning

confidence: 99%

Older Men and Women Efficiently Absorb Vitamin B-12 from Milk and Fortified Bread

Russell

Baik

Kehayias

2001

The Journal of Nutrition

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Nothing is directly known about the bioavailability of vitamin B-12 from dairy products or fortified grain products. We directly studied vitamin B-12 absorption from water, milk and fortified bread in adult subjects using 58 Co-labeled vitamin B-12 and a whole body gamma-ray counter/spectrophotometer. Sixteen healthy men and women over the age of 60 y with normal serum levels of vitamin B-12 and normal basal gastric acid secretion were studied.

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Inhibitory Effect of Eggs on Vitamin B₁₂ Absorption: Description of a Simple Ovalbumin ⁵⁷Co‐Vitamin B₁₂ Absorption Test

Cited by 71 publications

References 35 publications

Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

Vitamin Status of Healthy Subjects in Burgundy (France)

Older Men and Women Efficiently Absorb Vitamin B-12 from Milk and Fortified Bread

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