Inhibitory effect of deuterium oxide on glucose oxidation by pancreatic islets

Beckmann, J.; Holze, Susanne

doi:10.1016/0303-7207(80)90038-6

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Multiple lines of evidence suggest that D 2 O inhibits insulin release from pancreatic islets by stabilizing the microtubular system of the β-cells or by inhibiting oxidative phosphorylation [20][21][22]. In addition, the intracellular H + -concentration plays a critical role in the glucose-induced, time-dependent potentiation of insulin release in pancreatic β-cells, as well [23].…”

Section: Introductionmentioning

confidence: 99%

Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration

et al. 2021

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Deuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. In a phase II clinical study, deuterium depletion reduced fasting glucose concentration and insulin resistance. In this study, we tested the effect of subnormal D-concentration on glucose metabolism in a streptozotocin (STZ)-induced diabetic rat model. Animals were randomly distributed into nine groups to test the effect of D2O (in a range of 25–150 ppm) on glucose metabolism in diabetic animals with or without insulin treatment. Serum glucose, fructose amine-, HbA1c, insulin and urine glucose levels were monitored, respectively. After the 8-week treatment, membrane-associated GLUT4 fractions from the soleus muscle were estimated by Western blot technique. Our results indicate that, in the presence of insulin, deuterium depletion markedly reduced serum levels of glucose, -fructose amine, and –HbA1c, in a dose-dependent manner. The optimal concentration of deuterium was between 125 and 140 ppm. After a 4-week period of deuterium depletion, the highest membrane-associated GLUT4 content was detected at 125 ppm. These data suggest that deuterium depletion dose-dependently enhances the effect of insulin on GLUT4 translocation and potentiates glucose uptake in diabetic rats, which explains the lower serum glucose, -fructose amine, and –HbA1c concentrations. Based on our experimental data, deuterium-depleted water could be used to treat patients with metabolic syndrome (MS) by increasing insulin sensitivity. These experiments indicate that naturally occurring deuterium has an impact on metabolic regulations.

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Section: Introductionmentioning

confidence: 99%

Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Deuterium-Depleted Water Stimulates GLUT4 Translocation in the Presence of Insulin, Which Leads to Decreased Blood Glucose Concentration

Molnár

Horváth

Dankó

et al. 2021

Preprint

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Deuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. In a phase II clinical study, deuterium depletion reduced fasting glucose concentration and insulin resistance. In this study, we tested the effect of subnormal D-concentration on glucose metabolism in a streptozotocin (STZ)-induced diabetic rat model. Animals were randomly distributed into 9 groups to test the effect of D2O (in a range of 25–150 ppm) on glucose metabolism in diabetic animals with or without insulin treatment. Serum glucose, fructose amine-, HbA1c, –insulin and urine glucose levels were monitored, respectively. After the 8-week treatment, membrane associated GLUT4 fractions from the soleus muscle were estimated by Western blot technique. Our results indicate that, in the presence of insulin, deuterium depletion markedly reduced serum levels of glucose, -fructose amine, and –HbA1c, in a dose-dependent manner. The optimal concentration of deuterium was between 125–140 ppm. After a 4-week period of deuterium depletion, the highest membrane-associated GLUT4 content was detected at 125 ppm. This data suggests that deuterium depletion dose-dependently enhances the effect of insulin on GLUT4 translocation and potentiates glucose uptake in diabetic rats, which explains the lower serum glucose, -fructose amine, and –HbA1c concentrations. Based on our experimental data, deuterium-depleted water could be used to treat patients with metabolic syndrome (MS) by increasing insulin sensitivity. These experiments indicate that naturally occurring deuterium has an impact on metabolic regulations.

show abstract

“…Several lines of evidences suggest that D 2 O inhibits insulin release from pancreatic islets by stabilizing the microtubular system of the β-cells or by inhibiting oxidative phosphorylation [20][21][22]. However, the intracellular H + -concentration has a critical role in glucose-induced time-dependent potentiation of insulin release in pancreatic cells, too [23].…”

Section: Introductionmentioning

confidence: 99%

Deuterium-depleted Water Stimulates GLUT4 Translocation in the Presence of Insulin, which Leads to Decreased Blood Glucose Concentration

Molnár

Horváth

Dankó

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundDeuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. In a phase II clinical study, deuterium depletion reduced the fasting glucose concentration and insulin resistance.MethodsIn the study, we tested the effect of subnormal D-concentration on glucose metabolism in streptozotocin (STZ)-induced diabetic rat model. Animals were randomly distributed into 9 groups to test the effect of D2O (in a range of 25-150 ppm) on glucose metabolism in diabetic animals with or without 2X1 unit/day insulin treatment. Serum glucose, -fructose amine-, -HbAIC, –insulin, and urine glucose were tested. After the 8-week treatment, membrane associated GLUT-4 from soleus muscle content was estimated by Western blot technique.ResultsOur results indicate, that deuterium depletion in the presence of insulin reduced the serum glucose, -fructose amine, and -HbAIC, level on dose dependent manner. The optimal concentration of deuterium was between 125-140 ppm. After 8-week period of deuterium depletion the highest membrane-associated GLUT-4 content was detected at 125 ppm.ConclusionsThese data suggest that deuterium depletion dose-dependently enhances insulin’s effect on GLUT-4 translocation and potentiates glucose uptake in diabetic rats, which explains the lower serum glucose, -fructose amine, and -HbAIC concentrations. Based on our experimental data, deuterium-depleted water could be used to treat patients with metabolic syndrome (MS) by increasing the insulin sensitivity. The experiment indicates that the naturally occurring deuterium has an impact on metabolic regulation.

show abstract

Inhibitory effect of deuterium oxide on glucose oxidation by pancreatic islets

Cited by 4 publications

References 13 publications

Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration

Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration

Deuterium-Depleted Water Stimulates GLUT4 Translocation in the Presence of Insulin, Which Leads to Decreased Blood Glucose Concentration

Deuterium-depleted Water Stimulates GLUT4 Translocation in the Presence of Insulin, which Leads to Decreased Blood Glucose Concentration

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