Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure–activity relationships

Simon, Alain; Allais, Daovy; Duroux, Jean‐Luc; Basly, Jean‐Philippe; Durand-Fontanier, Sylvaine; Delage, Christiane

doi:10.1016/s0304-3835(98)00092-5

Cited by 170 publications

(120 citation statements)

References 24 publications

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“…These results are in agreement with previous reports that showed that curcumin suppresses the proliferation of a wide variety of tumor cells (Mehta et al, 1997;Anto et al, 2002;Kuo et al, 1996;Jiang et al, 1996;Ranjan et al, 1999;Piwocka et al, 1999;Han et al, 1999;Simon et al, 1998;Ramachandran and You, 1999;Bhaumik et al, 1999), including both B cell and T cell leukemia, colon carcinoma, breast carcinoma, prostate cancer cells and other tumor cell types. How curcumin suppresses the proliferation of tumor cells is not well understood.…”

Section: Figuresupporting

confidence: 93%

“…We and others have previously shown that curcumin (diferuloylmethane), a chemopreventive agent, is a potent down-regulator of NF-kB activation, most likely through the suppression of IkBa kinase (IKK) needed for NF-kB activation and it inhibits NFkB-mediated gene expression (Singh and Aggarwal, 1995;Kumar et al, 1998;Plummer et al, 1999;Jobin et al, 1999). Curcumin is also known to suppress the proliferation of a wide variety of tumor cells, including breast and prostate cancer cells (Mehta et al, 1997;Anto et al, 2002;Kuo et al, 1996;Jiang et al, 1996;Ranjan et al, 1999;Piwocka et al, 1999;Han et al, 1999;Simon et al, 1998;Ramachandran and You, 1999;Bhaumik et al, 1999), through a mechanism which is incompletely understood. We hypothesized that curcumin must mediate its antiproliferative effects through down-regulation of cyclin D1.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

et al. 2002

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Cyclin D1 is a proto-oncogene that is overexpressed in many cancers including breast and prostate. It plays a role in cell proliferation through activation of cyclin-dependent kinases. Curcumin, a diferuloylmethane, is a chemopreventive agent known to inhibit the proliferation of several breast and prostate cancer cell lines. It is possible that the effect of curcumin is mediated through the regulation of cyclin D1. In the present report we show that inhibition of the proliferation of various prostate, breast and squamous cell carcinoma cell lines by curcumin correlated with the down-regulation of the expression of cyclin D1 protein. In comparison, the down-regulation by curcumin of cyclin D2 and cyclin D3 was found only in selective cell lines. The suppression of cyclin D1 by curcumin led to inhibition of CDK4-mediated phosphorylation of retinoblastoma protein. We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis. We found that curcumin also down-regulated mRNA expression, thus suggesting transcriptional regulation. Curcumin also inhibited the activity of the cyclin D1 promoter-dependent reporter gene expression. Overall our results suggest that curcumin down-regulates cyclin D1 expression through activation of both transcriptional and post-transcriptional mechanisms, and this may contribute to the antiproliferative effects of curcumin against various cell types.

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Section: Figuresupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

et al. 2002

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“…It also suppresses the proliferation of a number of transformed cell types in vitro, including breast (Simon et al, 1998;Ramachandran and You, 1999), colon (Chen et al, 1999) and oral epithelial cells (Khafif et al, 1998). The anti-proliferative effects of curcumin include blocks at specific cell cycle stages, particularly a G2/M block (Hanif et al, 1997;Mehta et al, 1997;Ramachandran and You, 1999;Holy, 2002).…”

Section: Introductionmentioning

confidence: 99%

Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells

Kim¹,

Kim

Kang

et al. 2009

Exp Mol Med

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Curcumin is a well known natural polyphenol product isolated from the rhizome of the plant Curcuma longa, anti-inflammatory agent for arthritis by inhibiting synthesis of inflammatory prostaglandins. However, the mechanisms by which curcumin regulates the functions of chondroprogenitor, such as proliferation, precartilage condensation, cytoskeletal organization or overall chondrogenic behavior, are largely unknown. In the present report, we investigated the effects and signaling mechanism of curcumin on the regulation of

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“…Simon et al reported that DMC showed the highest anti-tumor bioactivity in three different curcuminoids to breast cancer cells (19). DMC also induced G2/M phase arrest and apoptosis in human glioma U87 cells (13).…”

Section: Discussionmentioning

confidence: 99%

Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells

Zhang

Zhao

et al. 2012

Oncol Rep

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Abstract. Curcumin (CUR) is a natural agent that has been demonstrated to effectively inhibit prostate cancer growth. However, natural CUR is relatively unstable and can be easily degraded in vivo. Therefore, it is essential to develop other stable curcuminoids. Demethoxycurcumin (DMC) is a candidate that has been verified in several tumor types and has potential for the treatment of prostate cancer. In the present study, we investigated the effects of DMC on proliferation, apoptosis and migration of PC-3 cells. MTT assay results indicated that DMC inhibited PC-3 cell viability in a dose-and time-dependent manner, and DMC induced G2/M phase arrest. Furthermore, PC-3 cells in DMC-treated groups had a higher apoptotic rate compared with DMSO-treated control. This effect may be due to the activation of the caspase-3 pathway. In DMC-treated groups, migrating and invasive cells were dramatically reduced (P<0.05). The activity of MMP-2, which is correlated with migration and invasion was also suppressed by DMC. These results indicated that DMC may inhibit PC-3 cell migration and invasion partially by affecting MMP-2 activity. In conclusion, DMC significantly inhibits proliferation, migration and invasion of cultured PC-3 cells, and this study may provide evidence for future in vivo studies and clinical use. IntroductionProstate cancer is a common urologic malignant tumor, which is threatening more and more people currently. The emerging studies on cancer prevention and treatment with natural products expand the traditional treatment of prostate cancer (1). Curcuminoids are phenolic coloring compounds that can be extracted from the rhizomes of Curcuma longa linn. Curcumin (CUR), a member of curcuminoids, has potent anti-tumor effects to prostate cancer (2-4) and several other cancers, such as breast (5) and colon cancer (6). However, CUR can be easily degraded both in vitro and in vivo (7,8). The anti-tumor activity of CUR will be enormously reduced, and this instability property of CUR limits its clinical use in cancer treatment. It is feasible to develop new stable compounds that are structurally similar as CUR but without the loss of anti-tumor activity. Demethoxycurcumin (DMC), an analogue of CUR, is one of such compounds. In comparison with CUR, the structure of DMC lacks one methoxy group directly linking to the benzene ring (Fig. 1). Although the structure difference between CUR and DMC is slight, the chemical characteristics of DMC is more stable (9,10). Previous studies have reported that DMC could inhibit renal and breast cancer cell growth (11,12) and induce G2/M phase arrest and apoptosis in human glioma U87 cells (13). These studies provide evidence that DMC might be a good substitute for CUR in cancer treatment. However, the effects of DMC on prostate cancer cells still remain unclear. Therefore, the present study was designed to investigate the effects of DMC on proliferation, apoptosis, migration and invasion in cultured human prostate cancer cells. In order to further explore the mechanisms of DMC on c...

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Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure–activity relationships

Cited by 170 publications

References 24 publications

Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells

Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells

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