2015
DOI: 10.1186/s12906-015-0534-6
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Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway

Abstract: BackgroundCurcuma purpurascens BI. (Zingiberaceae) commonly known as ‘Koneng Tinggang’ and ‘Temu Tis’ is a Javanese medicinal plant which has been used for numerous ailments and diseases in rural Javanese communities. In the present study, the apoptogenic activity of dichloromethane extract of Curcuma purpurascens BI. rhizome (DECPR) was investigated against HT-29 human colon cancer cells.MethodsAcute toxicity study of DECPR was performed in Sprague–Dawley rats. Compounds of DECPR were analyzed by the gas chro… Show more

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Cited by 32 publications
(37 citation statements)
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“…This study was conducted to evaluate the in vitro effects of complex C1, a new monoorganotin Schiff base complex, against MDA-MB-231 cells and derived MDA-MB-231 breast cancer stem cells/progenitors. One of the primary goals in the field of cancer drugs is the development of agents with more specificity for cancer cells and less toxicity to humans3233.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This study was conducted to evaluate the in vitro effects of complex C1, a new monoorganotin Schiff base complex, against MDA-MB-231 cells and derived MDA-MB-231 breast cancer stem cells/progenitors. One of the primary goals in the field of cancer drugs is the development of agents with more specificity for cancer cells and less toxicity to humans3233.…”
Section: Discussionmentioning
confidence: 99%
“…The LDH release increased significantly after treatment in a concentrated manner, indicating a loss of membrane integrity and cell death33. Additionally, the translocation of phosphatidylserine (PS) from the internal layer of the plasma membrane to the external cell surface is a marker of early stages of apoptosis3435.…”
Section: Discussionmentioning
confidence: 99%
“…SMMC7721 cells were treated with a number of LfcinB-P13 concentrations (range, 0-60 µg/ml) for 24 h at 37˚C. The treated cells were harvested prior to the preparation of cell lysates using Triton X-100 (Sigma-Aldrich; Merck Millipore, Darmstatd, Germany) as previously described (12). The reaction buffer containing the fluorogenic peptide substrates Ac-DEVD-AMC (caspase-3) or Ac-LEHD-AMC (caspase-9) was added to the cell lysates, which were incubated at 37˚C in the dark for 2 h. Caspase-3 and -9 activation in SMMC7721 cells was measured using the Infinite ® 200 PRO (Tecan Group, Ltd., Männedorf, Switzerland) microplate reader at 390 nm for excitation and 500 nm for emission.…”
Section: Methodsmentioning
confidence: 99%
“…A kivonat fokozta a kaszpáz-9 és a kaszpáz-3 aktiválódását, ezáltal apoptózist indukált a mitokondriális útvonalon, a kaszpáz-8 közvetlen aktiválása révén pedig gátolta a Bcl-2-t mRNS-expressziós szinten, ezáltal szintén fékezte a rákos sejtek burjánzását [17].…”
Section: Magyarországon Is Elérhető Ismertebb áJurvéda-gyógynövényekunclassified