“…Among these, polymethoxyflavones (PMFs), particularly in the peel of sweet oranges (Citrus sinensis) and mandarin oranges (Citrus reticulate), have been demonstrated to have various biological activities including anti-carcinogenic, anti-inflammatory and antitumor activities [19,20]. Our pervious studies also reported that 5-hydroxy- 3,6,7,8,3 0 ,4 0 -hexamethoxyflavone isolated from sweet orange peel extract shows the inhibitory effects against TPA-induced skin inflammation and tumor promotion in mice [21]. The most known and studied citrus PMF, nobiletin, has been reported in inhibition of AOMinduced colonic ACF formation in male F344 rats [22,23].…”