Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo

Hayashi, Katsumi; Imanishi, Nobuko; Kashiwayama, Yoshinori; Kawano, Atsushi; Terasawa, Katsutoshi; Shimada, Yutaka; Ochiai, Hiroshi

doi:10.1016/j.antiviral.2007.01.003

Cited by 125 publications

(82 citation statements)

References 23 publications

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“…It has been reported that Ephedrae herba inhibits the growth of influenza viruses upon direct addition to cultures of infected cells owing to the suppression of acidified cellular compartments essential for the uncoating process of the influenza virus [21]. It has also been reported that trans-cinnamaldehyde, one of the principal constituents of essential oil derived from Cinnamomi cortex, induces a complete or partial reduction in influenza virus growth by the inhibition of viral protein synthesis [22]. Neuraminidase inhibitors are known to prevent influenza virus from being released from the surface of infected cells [23].…”

Section: Discussionmentioning

confidence: 99%

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed a Clinical, Non-Randomized Study in Children

Toriumi

Kamei²,

Murata³

et al. 2012

Forsch Komplementmed

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Background: In an influenza season where reduced effectiveness of oseltamivir was observed, we investigated the effectiveness of Maoto for influenza infection in children. Methods: Patients diagnosed with influenza by rapid diagnostic kit underwent treatment in one of the following groups: Maoto-treated group (group 1 (M)); oseltamivir-treated group (group 2 (O)); Maoto+oseltamivir-treated group (group 3 (M+O)); zanamivir-treated group (group 4 (Z)); and Maoto+zanamivir-treated group (group 5 (M+Z)). Results: In influenza A patients who completed the study (n = 150), the mean duration of fever after administration (DFA) was significantly shorter in group 3 (M+O) (31.1 h, p < 0.01) and in group 4 (Z) (35.2 h, p < 0.05), as compared to group 2 (O) (56.0 h). Among these, in patients aged ≤5 years (n = 54), DFA was significantly shorter in group 1 (M) (33.2 h, p < 0.05) and in group 3 (M+O) (34.6 h, p < 0.05), as compared to group 2 (O) (61.4 h). In influenza B patients who completed the study (n = 70), no significant differences in DFA were observed among the groups. Conclusion: Maoto may be useful, particularly in cases of influenza with low sensitivity to oseltamivir and in patients aged ≤5 years for whom the use of zanamivir is difficult.

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Section: Discussionmentioning

confidence: 99%

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed a Clinical, Non-Randomized Study in Children

Toriumi

Kamei²,

Murata³

et al. 2012

Forsch Komplementmed

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“…Kampo medicines could show potential pharmacological effects through transformation to active metabolites in the liver after their metabolism and absorption in the small intestine, [29][30][31][32][33] although confirmation of these effects using both in vitro and in vivo experiments is necessary. 34) We are currently planning to investigate the effects of in vivo administration of BOT, BTS and OGT on obesity in mice fed a highfat diet, although it is also important to further clarify the usefulness of these three Kampo medicines in randomized control trials in clinical settings.…”

Section: Discussionmentioning

confidence: 99%

The Kampo Medicines Orengedokuto, Bofutsushosan and Boiogito Have Different Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes: Comprehensive Analysis of Genetic Profiles

Yamakawa

Ishigaki

Takano

et al. 2008

Biological & Pharmaceutical Bulletin

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Metabolic syndrome, wherein patients have both diabetes mellitus and dyslipidemia, is reaching epidemic proportions due to dietary factors and sedentary lifestyles.1) A major cause of mortality in these patients is atherosclerotic macrovascular diseases, the majority of which result from dyslipidemia associated with insulin-resistant diabetes. Adipose tissues, which were once thought to function primarily as passive depots for storage of excess lipid, are now understood to play crucial roles in metabolic regulation, feeding behavior and secretion of a variety of metabolic hormones. 2,3)Excessive accumulation of adipose cells in obesity contributes to the development of metabolic and cardiovascular diseases, as well as certain cancers. 4,5) Adipocytes accumulate energy in the form of triacylglycerols, which can be hydrolyzed and released as glycerol plus free fatty acids. When energy intake is dominant, excess lipid storage in white adipose tissues can be established through an increase in the size of mature adipocytes and/or recruitment of preadipocytes. This situation may lead not only to obesity but also to related pathophysiological conditions, such as type 2 diabetes mellitus, since adipose tissues are not only insulin-responsive tissues that convert glucose into fat stores, but also endocrine organs participating in energy balance regulation.6,7) Adipogenesis has been extensively studied in vitro using murine preadipocyte lineages and rat white adipocytes. Adipose conversion from such fibroblastic precursors is divided into at least three steps, namely cell commitment, clonal amplification and phenotype expression. 8)The initial step involves the induction of expression of several adipose-specific genes, whereas later events result in the appearance of the functional characteristics of mature adipocytes, such as increased glucose transport capacity, through the expression of insulin-responsive glucose transporters, which represent a key step in lipogenesis, thereby leading to progressive lipid accumulation. As a key factor for controlling the adipose mass in adipocytes, examination of the inhibitory activities of substances on excess lipid storage in white adipocytes represents a rational strategy for preventing obesity.Orengedokuto (OGT), Bofutsushosan (BTS) and Boiogito (BOT) are well-known Japanese, Korean and Chinese traditional herbal medicines used to clinically prevent or improve obesity. BTS has been reported to inhibit atherosclerosis, 9) obesity, 10) hypertension 11) and hyperglycemia. 12) However, Three Kampo medicines, Boiogito (BOT), Bofutsushosan (BTS) and Orengedokuto (OGT), used for obese patients were investigated for their effects on adipogenesis in cultured rat white adipocytes. Administration of the three extracts suppressed adipogenesis in concentration-dependent manners (1-100 m mg/ml) without any cytotoxicity. Changes in mRNA expression levels were analyzed using a Rat 230 2.0 Affymetrix GeneChip® microarray system. DNA microarray analysis (total probe set: 31099) using cDNAs prepared...

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“…22 As for the fourth substance CA, it could inhibit viral protein synthesis at the post-transcriptional level and increase survival rates of the cell that was infected with the lung-adapted PR-8 virus in mice, according to in vivo and in vitro studies. 23 CA is a natural aromatic fatty acid, and it has used by human with a long history. 24 It is now allowed to be used in commercial products as flavoring and has become ubiquitous in products containing cinnamon oil and almost in all plants.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Hesperidin, Ferulic Acid, Cinnamic Acid and Cinnamaldehyde in Chinese Tonic Wine by High Performance Liquid Chromatography

Lin¹,

Cham²,

Wu³

2010

J Chinese Chemical Soc

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This study aims to establish a HPLC method for the simultaneous determination of hesperidin (HE), ferulic acid (FA), cinnamic acid (CA) and cinnamaldehyde (CAD) in a Chinese tonic wine, Ma-Zu-WanShow-Yao-Jyo. After filtering the tonic wine, the filtrate was separated on a C18 column (250´4.6 mm, 5 mm) by gradient elution of acetonitrile-aqueous solution. The regression equations were linear (r ³ 0.9999) in the range of 1.5-150.0 mg/mL for HE, 0.3-60.0 mg/mL for FA, 0.06-6.0 mg/mL for CA, and 0.1-80.0 mg/mL for CAD. The relative standard deviation and relative error were less than 5.0% and 4.0%, respectively, for intra-and inter-day analyses. The limits of detection (LOD) were 0.6, 0.075, 0.012 and 0.02 mg/mL for HE, FA, CA and CAD (S/N = 3, 20 ml injection) respectively. This method can be used to standardize the quality control of Chinese tonic wine to ensure accuracy and efficiency in the future.

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Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo

Cited by 125 publications

References 23 publications

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed a Clinical, Non-Randomized Study in Children

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed a Clinical, Non-Randomized Study in Children

The Kampo Medicines Orengedokuto, Bofutsushosan and Boiogito Have Different Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes: Comprehensive Analysis of Genetic Profiles

Simultaneous Determination of Hesperidin, Ferulic Acid, Cinnamic Acid and Cinnamaldehyde in Chinese Tonic Wine by High Performance Liquid Chromatography

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Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo

Cited by 125 publications

References 23 publications

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed  a Clinical, Non-Randomized Study in Children

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed  a Clinical, Non-Randomized Study in Children

The Kampo Medicines Orengedokuto, Bofutsushosan and Boiogito Have Different Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes: Comprehensive Analysis of Genetic Profiles

Simultaneous Determination of Hesperidin, Ferulic Acid, Cinnamic Acid and Cinnamaldehyde in Chinese Tonic Wine by High Performance Liquid Chromatography

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Product

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Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed a Clinical, Non-Randomized Study in Children

Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed a Clinical, Non-Randomized Study in Children