Inhibitory effect of choriocarcinoma-derived high molecular weight factor (HMWF) on lymphocyte proliferation and adhesion to trophoblasts

Bourinbaiar, Aldar S.; Tan, Xin

doi:10.1016/0165-0378(93)90004-2

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…Therefore, additional mechanisms to overcome the anti‐tumor immunity in the pregnant uterus are necessary to explain the existence of gestational choriocarcinoma. Besides different other immune suppressor and suppressor–inducer molecules, which were described to be produced by choriocarcinoma cells, 36–40 the expression of FasL is a very likely candidate as this molecule endows choriocarcinoma cells with a tool to modulate their immunologic environment to their own benefit.…”

Section: Discussionmentioning

confidence: 99%

Expression of Functional Fas Ligand in Choriocarcinoma

Hammer¹,

Hartmann²,

Sedlmayr³

et al. 2002

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Expression of Functional Fas Ligand in Choriocarcinoma

Hammer¹,

Hartmann²,

Sedlmayr³

et al. 2002

American J Rep Immunol

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Failure of neutralizing gp120 monoclonal antibodies to prevent HIV infection of choriocarcinoma-derived trophoblasts

Bourinbaiar¹,

Borkowsky

Krasinski

et al. 1997

J Biomed Sci

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Although placental trophoblasts, the only fetal cells in direct contact with infectious maternal blood, can be infected with HIV, the precise cause for the low transmission rate of virus across the placental barrier is unknown. One of the most common conjectures is that maternal anti-HIV antibodies (Abs) contribute to the protection of the fetus. This hypothesis has been tested in vitro by infecting the CD4-negative placental trophoblast line, BeWo, with HIV-1(IIIB) in the presence of serial dilutions of neutralizing monoclonal Abs against the V3 loop (No. 694) or CD4-binding conformational domain (No. 588). The results, based on measurement of p24 production from virus-exposed cells, reveal that the titers of Abs, adequate in preventing the infection of control MT-4 T lymphocytes, were less effective in protecting trophoblasts. Furthermore, PCR analysis of HIV DNA formed after a single round of infection has shown no significant decrease in the number of viral copies in Ab-protected BeWo cells. An anti-HIV serum from a pregnant woman did also have no effect. Although our in vitro observations do not necessarily apply to the in vivo situation, the results suggest that the humoral immune response sustained by neutralizing Abs may be able to protect T lymphocytes, but not placental trophoblasts. The findings are consistent with recent clinical studies demonstrating a lack of correlation between the presence of neutralizing anti-HIV Abs in pregnant women and HIV transmission in utero. Copyright 1997 S. Karger AG, Basel

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Anti-HIV effect of beta subunit of human chorionic gonadotropin (βhCG) in vitro

Bourinbaiar

Lee‐Huang

1995

Immunology Letters

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Inhibitory effect of choriocarcinoma-derived high molecular weight factor (HMWF) on lymphocyte proliferation and adhesion to trophoblasts

Cited by 6 publications

References 17 publications

Expression of Functional Fas Ligand in Choriocarcinoma

Expression of Functional Fas Ligand in Choriocarcinoma

Failure of neutralizing gp120 monoclonal antibodies to prevent HIV infection of choriocarcinoma-derived trophoblasts

Anti-HIV effect of beta subunit of human chorionic gonadotropin (βhCG) in vitro

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