Inhibitory Effect of an Ethanol Extract Mixture of Vitis amurensis, Aralia cordata, and Glycyrrhizae radix on Amyloid β Protein (25-35)-Induced Neurotoxicity

Abstract

: The present study investigated an ethanol extract (SSB) of a mixture of three medicinal plants of Vitis amurensis, Aralia cordata, and Glycyrrhizae radix for possible neuroprotective effects on neurotoxicity induced by Amyloid β protein (Aβ) (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) . From these results, it is suggested that antidementia effect of SSB is due to its neuroprotective effect against Aβ (25-35)-induced neurotoxicity and that SSB may have a therapeutic role in preventing the progression of Alzheimer's disease.

The genus Glycyrrhiza (Fabaceae family) and its active constituents as protective agents against natural or chemical toxicities

“…Based on the studies, G. uralensis as a crud extract or mixture of medicinal plants could strongly prevent Aβ25‐35‐induced neuronal death. This neuroprotective effect of G. uralensis is performed by decreasing lipid peroxide, ROS generation, intracellular calcium concentration, pro‐apoptotic bax, and caspase‐3, and also through inhibition of DNA fragmentation and karyopyknosis (Ahn, Kim, Jung, & Ha, 2010; Jang & Seong, 2014; Kanno et al, 2013). The neuronal toxicity of Aβ has been ameliorated in pc12 cells treated with water extract of licorice by increasing mitochondrial transmembrane potential, antiapoptotic Bcl‐2, and poly (ADP‐ribose) polymerase (Ahn et al, 2010).…”

“…Licorice extract and its derivatives are known for pharmacological properties, including antiinflammatory (Schröfelbauer et al, 2009), antimicrobial and antiviral (Kaur, Kaur, & Dhindsa, 2013), antiprotozoal (Ali, 2013), antioxidant (Dirican & Turkez, 2014;Pastorino et al, 2018), anticancer (Ali, 2013), antihyperglycemic (Kaur et al, 2013), neuroprotective (Jang & Seong, 2014), antihyperlipidemic, and hepatoprotective (Hosseinzadeh & Nassiri-Asl, 2015). Different pharmacological effects of licorice have been shown in Figure 2.…”