2022
DOI: 10.1248/bpb.b22-00362
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Inhibitory Effect of a Late Sodium Current Blocker, NCC-3902, on the Automaticity of the Guinea Pig Pulmonary Vein Myocardium

Abstract: The effect of blocking the persistent component of the sodium channel current (late I Na ) on the automatic activity of the isolated guinea pig pulmonary vein myocardium was examined. NCC-3902 blocked late I Na , but did not affect other major ion channel currents stably expressed in cell lines. In isolated pulmonary vein cardiomyocytes, NCC-3902 blocked the late I Na induced by a ramp depolarizing voltage clamp pulse similar to that of the pacemaker depolarization observed in the pulmonary vein myocardium. In… Show more

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Cited by 5 publications
(2 citation statements)
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References 31 publications
(34 reference statements)
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“…13) On the other hand, GS-458967 and NCC-3902, highly selective blockers of late I Na , were reported to decrease the contractile force of isolated myocardium only slightly. 4,14) It appears that selective blockade of late I Na causes only a weak negative inotropy.…”
Section: Discussionmentioning
confidence: 99%
“…13) On the other hand, GS-458967 and NCC-3902, highly selective blockers of late I Na , were reported to decrease the contractile force of isolated myocardium only slightly. 4,14) It appears that selective blockade of late I Na causes only a weak negative inotropy.…”
Section: Discussionmentioning
confidence: 99%
“…All experiments were approved by the Ethics Committee of Toho University Faculty of Pharmaceutical Sciences (22-41-507) and performed in accordance with the Guiding Principles for the Care and Use of Laboratory Animals approved by The Japanese Pharmacological Society. The basic experimental setup and procedures were the same as those in our previous studies [ 6 , 7 , 15 , 16 , 21 , 22 , 23 , 40 , 41 , 42 , 43 ].…”
Section: Methodsmentioning
confidence: 99%