Inhibitory effect of a dendritic epidermal T cell line on K1735 melanoma cells in vivo and in vitro

Love-Schimenti, Cheryl D.; Kripke, Margaret L.

doi:10.1002/jlb.55.3.379

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…After 10 weeks large numbers of Vγ3‐ CD3+CD4‐CD8‐ T cells appeared in the epidermis, around the time the first AKs appeared. DETCs display non‐MHC‐restricted killing of various skin‐derived tumor cells, but no killing of normal keratinocytes (43–45), suggesting they form a first line of defense against tumor cells. And the DETCs appear to be important in the immunization for CD8+ T cell‐mediated cytotoxicity against UV‐induced tumors (46).…”

Section: Uv Exposure and Tolerance Toward Skin Tumorsmentioning

confidence: 99%

UV‐induced Immunosuppression in the Balance^†

Gruijl¹

2007

Photochem & Photobiology

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Around 1980, experiments with hairless mice showed us that UV‐induced actinic keratoses (AK) and ensuing skin carcinomas did not arise independently: the rate of occurrence in one skin area was increased considerably if AKs had already been induced separately in another distant skin area, i.e. a systemic effect. The ground laying work of Margaret Kripke in the 1970s provided a fitting explanation: UV‐induced immunosuppression and tolerance toward the UV‐induced tumors. From Kripke’s work a new discipline arose: “Photoimmunology.” Enormous strides were made in exploring and expanding the effects from UV carcinogenesis to infectious diseases, and in elucidating the mechanisms involved. Stemming from concerns about a depletion of the ozone layer and the general impact of ambient UV radiation, the groups I worked in and closely collaborated with explored the anticipated adverse effects of UV‐induced immunosuppression on healthy individuals. An important turning point was brought about in 1992 when the group of Kevin Cooper reported that immunosuppression could be induced by UV exposure in virtually all human subjects tested, suggesting that this is a normal and sound physiological reaction to UV exposure. This reaction could actually protect us from illicit immune responses against our UV‐exposed skin, such as observed in idiopathic polymorphic light eruption. This premise has fruitfully rekindled the research on this common “sun allergy,” affecting to widely varying degrees about one in five Europeans with indoor professions.

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Section: Uv Exposure and Tolerance Toward Skin Tumorsmentioning

confidence: 99%

UV‐induced Immunosuppression in the Balance^†

Gruijl¹

2007

Photochem & Photobiology

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“…Патогенетическую основу терапии составили сведения об анергии иммунной защиты, связанной с экспрессией опухолевыми клетками биологических факторов, преобразующих функцию антигенпрезентирующих дендритных клеток в индукцию толерантности к опухолевой ткани, что в итоге ведет к превращению DC в «глушители» противоопухолевых иммунных реакций [13,14].…”

Section: ключевые слова: дендритные клетки иммунотерапия злокачественные новообразования меланомаunclassified

Opportunities and prospects of melanoma immunotherapy with dendritic cells application

Афанасьева¹,

Karetnikova²,

Shchetinin³

2021

Medical news of the North Caucasus

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“…Melanoma occupies 1% of cutaneous carcinoma cases but is the most lethal event in a cutaneous carcinoma patient. DETC cell line AU16 inhibits melanoma progression in vivo and kills melanoma cells in cytotoxicity in vitro ( 77 ). The DETC cell line AU16, derived from C3H mice, is an IL-2-dependent cell line and cytotoxic to melanoma cell lines and chemo-induced fibrosarcoma in vitro ( 77 ).…”

Section: Role Of Detc In Cutaneous Carcinomamentioning

confidence: 99%

“…DETC cell line AU16 inhibits melanoma progression in vivo and kills melanoma cells in cytotoxicity in vitro ( 77 ). The DETC cell line AU16, derived from C3H mice, is an IL-2-dependent cell line and cytotoxic to melanoma cell lines and chemo-induced fibrosarcoma in vitro ( 77 ). The injection of mixed AU16 cells and melanoma cells can delay the melanoma growth in vivo ( 77 ).…”

Section: Role Of Detc In Cutaneous Carcinomamentioning

confidence: 99%

“…The DETC cell line AU16, derived from C3H mice, is an IL-2-dependent cell line and cytotoxic to melanoma cell lines and chemo-induced fibrosarcoma in vitro ( 77 ). The injection of mixed AU16 cells and melanoma cells can delay the melanoma growth in vivo ( 77 ). In another study, the inhibition of DETCs to melanoma may be tumor specific as normal keratinocytes are not affected ( 56 ).…”

Section: Role Of Detc In Cutaneous Carcinomamentioning

confidence: 99%

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Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma

2020

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Dendritic epidermal T cells (DETCs) are γδ T cells expressing invariant Vγ5Vδ1 T cell receptor (TCR) in murine epidermis. Initially, the development and the maturation of DETC progenitors are mediated by skint-1, TCR, and cytokines in the fetal thymus. Then, the DETC progenitors migrate to the epidermis with the guidance of selectins, CCR10, CCR4, etc . Eventually, mature DETCs proliferate and maintain a homeostatic population in the epidermis through IL-15 and aryl hydro-carbon receptor signaling. In “stressed” skin, DETCs are activated, exhibiting features such as a round morphology, cytotoxicity, and production of cytokines. In cutaneous carcinoma, DETCs generally inhibit tumor development directly in non-major histocompatibility complex-restricted manner, with the assistance of cytokines. DETCs also recognize and inhibit tumor via TCR, non-TCR receptors (such as 2B4 and NKG2D), or both. This study summarizes the biogenesis and the function of DETCs in cutaneous carcinoma and clarifies the essential surveillance role in the epidermis that DETCs play. As there are no DETCs in human epidermis but only human epidermis γδ T cells, we need to understand the anti-tumor pathways used by DETCs to find analogous immune pathways in human skin, which could be exploited for novel therapeutics.

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Inhibitory effect of a dendritic epidermal T cell line on K1735 melanoma cells in vivo and in vitro

Abstract: Abstract:Murine epidermis contains a resident population of dendritic epidermal T cells (DETCs) with unknown function.

Cited by 10 publications

References 15 publications

UV‐induced Immunosuppression in the Balance^†

UV‐induced Immunosuppression in the Balance^†

Opportunities and prospects of melanoma immunotherapy with dendritic cells application

Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma

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Inhibitory effect of a dendritic epidermal T cell line on K1735 melanoma cells in vivo and in vitro

Abstract: Abstract:Murine epidermis contains a resident population of dendritic epidermal T cells (DETCs) with unknown function.

Cited by 10 publications

References 15 publications

UV‐induced Immunosuppression in the Balance†

UV‐induced Immunosuppression in the Balance†

Opportunities and prospects of melanoma immunotherapy with dendritic cells application

Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma

Contact Info

Product

Resources

About

UV‐induced Immunosuppression in the Balance^†

UV‐induced Immunosuppression in the Balance^†