Inhibitory connections between antagonistic motor neurones of the crayfish walking legs

Pearlstein, Édouard; Watson, A.H.D.; Bévengut, M.; Cattaert, D.

doi:10.1002/(sici)1096-9861(19980921)399:2<241::aid-cne7>3.3.co;2-t

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…5D). Direct reciprocal inhibition between antagonistic MNs 62,63 would then result in the more depolarized group alone being active, while the antagonistic one is inhibited (Fig. 5E).…”

Section: Modulation Of Polysynaptic Pathwaysmentioning

confidence: 99%

Central control components of a ‘simple’ stretch reflex

Clarac¹,

Cattaert²,

Ray³

2000

Trends in Neurosciences

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The monosynaptic stretch reflex is a fundamental feature of sensory-motor organization in most animal groups. In isolation, it serves largely as a negative feedback devoted to postural controls; however, when it is involved in diverse movements, it can be modified by central command circuits. In order to understand the implications of such modifications, a model system has been chosen that has been studied at many different levels: the crayfish walking system. Recent studies have revealed several levels of control and modulation (for example, at the levels of the sensory afferent and the output synapse from the sensory afferent, and via changes in the membrane properties of the postsynaptic neuron) that operate complex and highly adaptive sensory-motor processing. During a given motor task, such mechanisms reshape the sensory message completely, such that the stretch reflex becomes a part of the central motor command.

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“…5D). Direct reciprocal inhibition between antagonistic MNs 62,63 would then result in the more depolarized group alone being active, while the antagonistic one is inhibited (Fig. 5E).…”

Section: Modulation Of Polysynaptic Pathwaysmentioning

confidence: 99%

Central control components of a ‘simple’ stretch reflex

Clarac¹,

Cattaert²,

Ray³

2000

Trends in Neurosciences

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show abstract

“…However, within this family of molecules, the specific role of histamine remains unknown. Several studies, including those based on central pattern generator models, indicate a role for this biogenic amine in tuning rhythmic bursting in invertebrates (Pearlstein, Watson, Bévengut, & Cattaert, ; Matsuura, Kanou, & Yamaguchi, ; Le et al, ; Sullivan et al, ; Buhl, Schildberger, & Stevenson, ).…”

Section: Introductionmentioning

confidence: 99%

Histamine modulates spinal motoneurons and locomotor circuits

Coslovich

Brumley

D’Angelo

et al. 2017

J of Neuroscience Research

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Spinal motoneurons and locomotor networks are regulated by monoamines, among which, the contribution of histamine has yet to be fully addressed. The present study investigates histaminergic regulation of spinal activity, combining intra- and extracellular electrophysiological recordings from neonatal rat spinal cord in vitro preparations. Histamine dose-dependently and reversibly generated motoneuron depolarization and action potential firing. Histamine (20 µM) halved the area of dorsal root reflexes and always depolarized motoneurons. The majority of cells showed a transitory repolarization, while 37% showed a sustained depolarization maintained with intense firing. Extracellularly, histamine depolarized ventral roots (VRs), regardless of blockage of ionotropic glutamate receptors. Initial, transient glutamate-mediated bursting was synchronous among VRs, with some bouts of locomotor activity in a subgroup of preparations. After washout, the amplitude of spontaneous tonic discharges increased. No desensitization or tachyphylaxis appeared after long perfusion or serial applications of histamine. On the other hand, histamine induced single motoneuron and VR depolarization, even in the presence of tetrodotoxin (TTX). During chemically induced fictive locomotion (FL), histamine depolarized VRs. Histamine dose-dependently increased rhythm periodicity and reduced cycle amplitude until near suppression. This study demonstrates that histamine induces direct motoneuron membrane depolarization and modulation of locomotor output, indicating new potential targets for locomotor neurorehabilitation.

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Inhibitory connections between antagonistic motor neurones of the crayfish walking legs

Cited by 2 publications

References 29 publications

Central control components of a ‘simple’ stretch reflex

Central control components of a ‘simple’ stretch reflex

Histamine modulates spinal motoneurons and locomotor circuits

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