Abstract:The effect of an alkylating agent, dianhydrogalactitol (DAG), on the humoral immune response of C57B1 mice immunized with sheep erythrocytes was studied. Different inhibitory or stimulatory effects could be achieved by varying the time and the dose of drug administration. DAG in a dose of 1.5 mg/kg given either before or after immunization induced enhanced immune responses. Higher doses (>5 mg/kg) administered in the inductive phase had a marked suppressive effect while treatments at this dosage preceding immu… Show more
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