Inhibitory and preventive effects of <i>Lactobacillus plantarum</i> FB-T9 on dental caries in rats

Zhang, Qiuxiang; Qin, Sujia; Yin, Heng; Xu, Xian‐Yan; Zhao, Jianxin; Zhang, Hao

doi:10.1080/20002297.2019.1703883

Cited by 15 publications

(14 citation statements)

References 43 publications

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“…Unlike current drugs, TSR332 showed a hyperuricemia-preventive effect, which is the most attractive finding of this study ( Luo et al, 2020 ; Zhang et al, 2020 ). According to the experimental scheme, rats in the pretreatment group were healthy and free from hyperuricemia during the period of probiotic administration.…”

Section: Discussionmentioning

confidence: 61%

Lactobacillus reuteri TSR332 and Lactobacillus fermentum TSF331 stabilize serum uric acid levels and prevent hyperuricemia in rats

Kuo

Hsieh

Chen

et al. 2021

PeerJ

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Background Uric acid (UA) is the end product of purine metabolism in the liver and is excreted by the kidneys. When purine metabolism is impaired, the serum UA level will be elevated (hyperuricemia) and eventually lead to gout. During evolution, humans and some primates have lost the gene encoding uricase, which is vital in UA metabolism. With the advances of human society, the prevalence of hyperuricemia has dramatically increased because of the refined food culture. Hyperuricemia can be controlled by drugs, such as allopurinol and probenecid. However, these drugs have no preventive effect and are associated with unpleasant side effects. An increasing number of probiotic strains, which are able to regulate host metabolism and prevent chronic diseases without harmful side effects, have been characterized. The identification of probiotic strains, which are able to exert beneficial effects on UA metabolism, will provide an alternative healthcare strategy for patients with hyperuricemia, especially for those who are allergic to anti-hyperuricemia drugs. Methods To elicit hyperuricemia, rats in the symptom control group (HP) were injected with potassium oxonate and fed a high-purine diet. Rats in the probiotic groups received the high-purine diet, oxonate injection, and supplements of probiotic strains TSR332, TSF331, or La322. Rats in the blank control group (C) received a standard diet (AIN-93G) and oxonate injection. Results Purine-utilizing strains of probiotics were screened using high-pressure liquid chromatography (HPLC) in vitro, and the lowering effect on serum UA levels was analyzed in hyperuricemia rats in vivo. We found that Lactobacillus reuteri strain TSR332 and Lactobacillus fermentum strain TSF331 displayed significantly strong assimilation of inosine (90%; p = 0.00003 and 59%; p = 0.00545, respectively) and guanosine (78%; p = 0.00012 and 51%; p = 0.00062, respectively) within 30 min in vitro. Further animal studies revealed that serum UA levels were significantly reduced by 60% (p = 0.00169) and 30% (p = 0.00912), respectively, in hyperuricemic rats treated with TSR332 and TSF331 for 8 days. Remarkably, TSR332 ameliorated the occurrence of hyperuricemia, and no evident side effects were observed. Overall, our study indicates that TSR332 and TSF331 are potential functional probiotic strains for controlling the development of hyperuricemia.

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Section: Discussionmentioning

confidence: 61%

Lactobacillus reuteri TSR332 and Lactobacillus fermentum TSF331 stabilize serum uric acid levels and prevent hyperuricemia in rats

Kuo

Hsieh

Chen

et al. 2021

PeerJ

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“…The ability of a probiotic to colonize the oral cavity is key to its function, and this ability is strain-specific. Lactobacillus family may effectively prevent biofilm formation, perhaps because L. plantarum (5D-3) had the advantage of precolonization of the oral cavity (Zhang et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effect of Probiotics Lactobacillus Supernatants Against Streptococcus Mutans and Preventing Biofilm Formation

Demir

2021

Turkish JAF Sci.Tech.

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Probiotic microorganisms can release bioactive substances that can inhibit the growth and biofilm formation of pathogenic microorganisms such as Streptococcus mutans. Dental caries is a multi-factorial chronic infection disease, which starts with bacterial biofilm formation caused mainly by S. mutans. This study investigated the characteristics of Lactobacillus spp. strains as an oral probiotic. Twelve Lactobacillus spp. species obtained from fermented milk and dairy products were identified. Antimicrobial activity was determined with the Minimum Inhibition Concentration against S. mutans as an oral pathogen. Biofilm formation capabilities of the identified Lactobacillus strains in supernatant and culture media were determined. In addition, their ability to α-amylase tolerance and pH values (24h-48h) were determined. L.plantarum showed the highest antimicrobial activity compare other Lactobacillus strains. Also, L. plantarum inhibited biofilm formation.

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“…Main cause of dental caries is Streptococcus mutans which leads to formation of plaque biofilm. The L.Plantarum FBT9 has a stronger inhibitory effect on cariogenic bacteria 17 . The hot steeping extract of tea contains catechins which have a higher inhibitory effect on biofilms 31 .…”

Section: Cont Table 1: Description and Quality Of Included Studiesmentioning

confidence: 98%

“…Streptococcus mutans is the main cause for dental caries which leads to formation of plaque biofilm. This plaque biofilm ensures caries development in any individual 17 . Actually, dental caries are due to the presence of four variables such as cariogenic bacteria (caries producing bacteria, like S.mutans), sugar(carbohydrate fermentation also causes dental caries), susceptible tooth surface and time.…”

Section: Causes Of Dental Cariesmentioning

confidence: 99%

Review on Caries Preventive Effect of Fluoride Toothpaste

2020

IJFMT

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Dental caries is defined as localized destruction of tooth tissue, mainly due to bacterial action causing demineralized foci on peripheral surfaces. Normally, children have the habit of brushing their teeth once a day using fluoridated toothpaste. Due to this,there is less decay of tooth in them, as fluoride being a mineral prevents tooth decay. There is a relationship between fluoride toothpaste and dental caries, if a toothpaste having 1000ppm of fluoride content, is associated with less decay of tooth, so the fluoride has caries preventive effect. The aim of the review is to find out the role of fluoride in caries preventive effect, to know fluoride toothpastes correct concentration to avoid fluorosis and other fluoride related ailments and finally to understand the advantages of fluoride toothpaste as preventive effect of dental caries. This research was conceived as scoping literature review. This review has accessed existing reviews and researches in the last decade mostly, through PMC database, MeSH, Google Scholar, Pubmed, Medline, CrossRef and the search terms included were 'dental caries', 'fluoride toothpaste', 'caries preventive effect', 'fluoride'. Considered research was limited to manuscripts related to English, dental caries, fluoride toothpaste (as caries preventive effect) and this review did not include or consider other oral problems, other preventive methods of dental caries, natural components that prevent caries attack. The description of included studies for the review is tabulated. The role of fluoride in dental caries, its correct concentration in fluoride toothpaste is known and the preventive effect of fluoride toothpaste on dental caries is well understood through this review. With these general guidelines, there is more possibility of preventing dental caries and excessive fluoride will not lead to fluorosis due to awareness of correct concentration of fluoride in fluoride toothpaste.

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Inhibitory and preventive effects of Lactobacillus plantarum FB-T9 on dental caries in rats

Cited by 15 publications

References 43 publications

Lactobacillus reuteri TSR332 and Lactobacillus fermentum TSF331 stabilize serum uric acid levels and prevent hyperuricemia in rats

Lactobacillus reuteri TSR332 and Lactobacillus fermentum TSF331 stabilize serum uric acid levels and prevent hyperuricemia in rats

Inhibitory Effect of Probiotics Lactobacillus Supernatants Against Streptococcus Mutans and Preventing Biofilm Formation

Review on Caries Preventive Effect of Fluoride Toothpaste

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