1992
DOI: 10.1016/0014-2999(92)90492-m
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Inhibitory and contractile effects of okadaic acid on rat uterine muscle

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Cited by 7 publications
(5 citation statements)
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“…Candenas and coworkers [20] first reported that OA could inhibit and stimulate uterine contractions at low (100 nM) and high (5 M) concentrations, respectively. Okadaic acid-stimulated uterine contractions are partially inhibited when transmembrane Ca 2ϩ movement was inhibited with Ca 2ϩ -free media plus EDTA [21,22].…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…Candenas and coworkers [20] first reported that OA could inhibit and stimulate uterine contractions at low (100 nM) and high (5 M) concentrations, respectively. Okadaic acid-stimulated uterine contractions are partially inhibited when transmembrane Ca 2ϩ movement was inhibited with Ca 2ϩ -free media plus EDTA [21,22].…”
Section: Discussionmentioning
confidence: 98%
“…Presently, there is a lack of agreement in regard to whether PP1 and/ or PP2A are the primary smooth muscle PP within these tissues. Likewise, OA has been shown to both inhibit and stimulate contractions of rat myometrial strips depending on concentrations used [20][21][22][23]. Low concentrations (100 Tissues were fixed, paraffin embedded, and exposed to microwave antigen retrieval prior to incubation with primary antibodies or NIRS (A1-A3) followed by biotinylated secondary antibody and colorimetric evaluation with avidin-biotin-peroxidase and DAB.…”
Section: Introductionmentioning
confidence: 99%
“…Okadaic acid mediates both vascular and intestinal smooth muscle contraction independent of extracellular calcium (Ozaki et al , 1987; Obara et al , 1989; Hirano et al , 1989) as a consequence of the inhibition of myosin light chain phosphatase (Takai et al , 1987; Ishihara et al , 1989). In other studies, okadaic acid has been shown to induce relaxation of vascular and uterine smooth muscle (Karaki et al , 1989; Candenas et al , 1992), while in human airways both excitatory and inhibitory effects have been observed (Naline et al , 1994). The mechanism underlying the inhibitory effect of okadaic acid on smooth muscle function is not clear but may relate to a reduction in calcium entry (Naline et al , 1994) and/or to an increase in the open probability of calcium‐dependent potassium channels (Kume et al , 1989).…”
Section: Introductionmentioning
confidence: 95%
“…Depolarizationinduced contractures as well as spontaneous or agonist-induced rhythmic oscillations are strictly dependent o n external Ca2+ and inhibited by Ltype calcium channel blockers (Parkington and Coleman, 1990;Arteche et al, 1995). W e have previously shown that O A induces both inhibitory and contractile effects in estrogen-primed rat myometrium (Candenas et al, 1992(Candenas et al, , 1994. The inhibitory effects appear at concentrations between 0.1 and 1 pM, lower than those needed to evoke a contractile response.…”
Section: Introductionmentioning
confidence: 96%