Inhibitory activity of thermal copolymers of amino acids for the metal-catalyzed hydrolysis of an RNA dinucleotide

Kawamura, Kunio; Nagahama, Minoru; Yao, Takeshi

doi:10.1016/j.asr.2006.06.011

Cited by 1 publication

(2 citation statements)

References 47 publications

(53 reference statements)

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“…433 In contrast to the above studies, a dinucleotide was protected from metal-ion-mediated hydrolysis by thermal copolymers of Gly, Ala, Glu, Asp, and His. 434 Non-covalent interactions between RNA and peptides have been shown to promote both peptide ligation and RNA ligation. Structurally distinct long RNAs could template the native chemical ligation of cationic peptides, both by nonspecific association and within designed complexes in which specific peptide binding sites were engineered into a ribozyme.…”

Section: Peptide Interactions With Nucleic Acidsmentioning

confidence: 99%

“…On the other hand, poly(Leu-Lys) was also found to promote the oligomerization of activated mononucleotide diphosphates, being especially effective in increasing the abundance of longer oligomers. , The cleavage of ribonucleotides was promoted by a set of 12-mer or 20-mer peptides that were enriched in Lys or His, especially in the presence of certain divalent metal ions; in contrast, an analogous Arg-rich 20-mer peptide did not promote RNA cleavage . In contrast to the above studies, a dinucleotide was protected from metal-ion-mediated hydrolysis by thermal copolymers of Gly, Ala, Glu, Asp, and His …”

Section: Peptide Interactions With Nucleic Acidsmentioning

confidence: 99%

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Prebiotic Peptides: Molecular Hubs in the Origin of Life

et al. 2020

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The fundamental roles that peptides and proteins play in today’s biology makes it almost indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to extrapolate back from extant biology to the prebiotic world, one must acknowledge the critical importance that interconnected molecular networks, likely with peptides as key components, would have played in life’s origin. In this review, we summarize chemical processes involving peptides that could have contributed to early chemical evolution, with an emphasis on molecular interactions between peptides and other classes of organic molecules. We first summarize mechanisms by which amino acids and similar building blocks could have been produced and elaborated into proto-peptides. Next, non-covalent interactions of peptides with other peptides as well as with nucleic acids, lipids, carbohydrates, metal ions, and aromatic molecules are discussed in relation to the possible roles of such interactions in chemical evolution of structure and function. Finally, we describe research involving structural alternatives to peptides and covalent adducts between amino acids/peptides and other classes of molecules. We propose that ample future breakthroughs in origin-of-life chemistry will stem from investigations of interconnected chemical systems in which synergistic interactions between different classes of molecules emerge.

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Section: Peptide Interactions With Nucleic Acidsmentioning

confidence: 99%