Inhibitory activity of metal-curcumin complexes on quorum sensing related virulence factors of Pseudomonas aeruginosa PAO1

Gholami, Mina; Zeighami, Habib; Bikas, Rahman; Heidari, Azam; Rafiee, Farzaneh; Haghi, Fakhri

doi:10.1186/s13568-020-01045-z

Cited by 24 publications

(26 citation statements)

References 34 publications

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“…P. aeruginosa possesses almost all of the known antimicrobial resistance mechanisms which is why empirical antibiotic treatments are often ineffective [ 16 ]. As a consequence, finding novel alternative therapeutic approaches is a necessity, targeting the bacterial social behaviors involved in their pathogenesis is one of these promising approaches [ 3 , 39 ]. Targeting the bacterial cell-to-cell communication quorum sensing system (QS) has several merits, particularly it avoids direct any effect on bacterial growth, decreasing the emergence of bacterial resistance [ 3 , 20 , 39 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa

et al. 2020

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Pseudomonas aeruginosa is a significant human pathogen, it possesses almost all of the known antimicrobial resistance mechanisms. Quorum sensing (QS) is an intercellular communication system that orchestrates bacterial virulence and its targeting is an effective approach to diminish its pathogenesis. Repurposing of drugs is an advantageous strategy, in this study we aimed to repurpose the anti-diabetic drugs sitagliptin, metformin and vildagliptin as anti-QS in P. aeruginosa. The effects of sub-inhibitory concentrations of the tested drugs on the expression of QS-encoding genes and QS-regulated virulence factors were assessed. The protective activity of tested drugs on P. aeruginosa pathogenesis was evaluated in vivo on mice. In silico analysis was performed to evaluate the interference capabilities of the tested drugs on QS-receptors. Although the three drugs reduced the expression of QS-encoding genes, only sitagliptin inhibited the P. aeruginosa virulence in vitro and protected mice from it. In contrast, metformin showed significant in vitro anti-QS activities but failed to protect mice from P. aeruginosa. Vildagliptin did not show any in vitro or in vivo efficacy. Sitagliptin is a promising anti-QS agent because of its chemical nature that hindered QS-receptors. Moreover, it gives an insight to consider their similar chemical structures as anti-QS agents or even design new chemically similar anti-QS pharmacophores.

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Section: Discussionmentioning

confidence: 99%

Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa

et al. 2020

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“…This complex inhibited Gram (+) bacteria S. aureus and Gram (−) E. coli culture-associated biofilms, which was found to be positively correlated with the inhibition of bacterial alkaline phosphatase activity as shown by in silico studies [35]. Another study showed that a Cu 2+ -curcumin complex at a concentration of 1/4 MIC on P. aeruginosa highly inhibited biofilm formation, swarming and twitching motilities, and alginate and pyocyanin production, thus indicating its efficacy for the therapy and management of P. aeruginosa infections [34]. Curcumin-ruthenium complex exhibited strong antibiofilm activity compared to some FDA approved drugs [31].…”

Section: Antimicrobialmentioning

confidence: 84%

“…Another study showed that Cu 2+ -curcumin complexes showed higher growth inhibition of P. aeruginosa compared to free curcumin, as the minimum inhibitory concentration (MIC) of Cu 2+ -curcumin complexes and free curcumin was 62.5 and 125 µg/mL, respectively. Moreover, Cu 2+ -curcumin complexes (62.5 µg/mL) reduced bacterial cell growth [34].…”

Section: Antimicrobialmentioning

confidence: 96%

“…Zinc-curcumin Increases antioxidant enzymes and decreases MDA level caused by cold-restraint stress in mice [17] Iron-curcumin Improves antioxidant activity [18] Gold NP-curcumin Shows good antioxidant activity [19] Silver-curcumin Presents good antioxidant activity and cell compatibility [20] Copper-curcumin Zinc-curcumin Enhances the superoxide dismutase, catalase, and glutathione peroxidase activities and attenuates MDA levels in PC12 cells [21] Copper-curcumin Exhibits antioxidant potential by scavenging DPPH radicals [11] Zinc NP-curcumin Exerts antioxidant activity as it scavenges ABTS+ and DPPH free radicals [22] Ruthenium-curcumin Exhibits potent antioxidant activity [23] Gallium-diacetylcurcumin Presents an increase in the antioxidant efficiency [24] Anti-inflammatory Zinc-curcumin Suppresses NF-κB, TGF-β1, IL-8, IL-6, TNF-α in rat model [25,26] Copper-curcumin Suppresses PKCδ and NF-κB [27] Zinc-curcumin Copper-curcumin Inhibits H 2 O 2 -induced NF-κB in PC12 cells [21] Gadolinium-curcumin Inhibits pIKKα, pIKKα/β, and NF-κB in pancreatic cancer cells [28] Anti-microbial Cobalt-, Nickel-, Copper-curcumin Inhibits growth of E. coli, S. aureus, K. pneumoniae, S. pyogenes, and P. aeruginosa [29] Zinc-curcumin Inhibits growth of P. aeruginosa [30] Zinc-curcumin Inhibits growth of B. subtilis, E. coli [22] Ruthenium-curcumin Inhibits growth of drug resistant S. aureus, reduces mean bacterial counts in murine model of Staphylococcus infection [31,32] Manganese-curcumin Inhibits growth of S. aureus, E. coli [32] Silver-curcumin Combats multiple bacteria-induced infections on wound surfaces [20] Copper-curcumin Exhibits antimicrobicidal activity [33] Copper-curcumin Inhibits growth of P. aeruginosa [34] Orthovanadium-curcumin Inhibits bacterial biofilm formation, growth of S. aureus and E. coli [35] Copper-curcumin Inhibits growth of P. aeruginosa and biofilm formation [34] Ruthenium-curcumin Exhibits strong antibiofilm activity [31] Zinc-curcumin Exerts potency against biofilm formation [30]…”

Section: Antioxidantmentioning

confidence: 99%

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Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Prasad

DuBourdieu²,

Srivastava³

et al. 2021

IJMS

116

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Curcumin, an active component of the rhizome turmeric, has gained much attention as a plant-based compound with pleiotropic pharmacological properties. It possesses anti-inflammatory, antioxidant, hypoglycemic, antimicrobial, neuroprotective, and immunomodulatory activities. However, the health-promoting utility of curcumin is constrained due to its hydrophobic nature, water insolubility, poor bioavailability, rapid metabolism, and systemic elimination. Therefore, an innovative stride was taken, and complexes of metals with curcumin have been synthesized. Curcumin usually reacts with metals through the β-diketone moiety to generate metal–curcumin complexes. It is well established that curcumin strongly chelates several metal ions, including boron, cobalt, copper, gallium, gadolinium, gold, lanthanum, manganese, nickel, iron, palladium, platinum, ruthenium, silver, vanadium, and zinc. In this review, the pharmacological, chemopreventive, and therapeutic activities of metal–curcumin complexes are discussed. Metal–curcumin complexes increase the solubility, cellular uptake, and bioavailability and improve the antioxidant, anti-inflammatory, antimicrobial, and antiviral effects of curcumin. Metal–curcumin complexes have also demonstrated efficacy against various chronic diseases, including cancer, arthritis, osteoporosis, and neurological disorders such as Alzheimer’s disease. These biological activities of metal–curcumin complexes were associated with the modulation of inflammatory mediators, transcription factors, protein kinases, antiapoptotic proteins, lipid peroxidation, and antioxidant enzymes. In addition, metal–curcumin complexes have shown usefulness in biological imaging and radioimaging. The future use of metal–curcumin complexes may represent a new approach in the prevention and treatment of chronic diseases.

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“…The complex [Cu(cur) 2 ] ( 60 ) (cur: curcumin) inhibited biofilm formation in the case of S. aureus and significantly repressed the expression of lasI and lasR genes, demonstrating its QS inhibitory effect [ 136 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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Inhibitory activity of metal-curcumin complexes on quorum sensing related virulence factors of Pseudomonas aeruginosa PAO1

Cited by 24 publications

References 34 publications

Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa

Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

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