Inhibitory activity of black mulberry (Morus nigra) extract against testicular, liver and kidney toxicity induced by paracetamol in mice

Diab, Kawthar A; Fahmy, Maha A.; Hassan, Emad M.; Hassan, Zeinab M.; Omara, Enayat A.; Abdel-Samie, Negm S.

doi:10.1007/s11033-020-05265-1

Cited by 19 publications

(7 citation statements)

References 55 publications

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“…No entanto, não há relatos científicos sobre a proteção testicular, as atividades hepato e nefroprotetora das folhas de M. nigra. Os componentes bioativos das folhas da amoreira-preta parecem ser bons candidatos para proteção genética, tratamento da organotoxicidade induzida pelo estresse oxidativo (DIAB, et al, 2020).…”

Section: Resultados E Discussõesunclassified

A fitoterapia Morus Nigra: como alternativa no tratamento dos sintomas da menopausa / Phytotherapy as an alternative in the treatment of menopause symptoms

Rodrigues¹,

Viera²,

Barros³

et al. 2021

BJDV

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Introdução: Quando ocorre aos sintomas da menopausa é possível analisar várias formas de tratamento que realmente possuem eficácia comprovada química e fisicamente. Além disso, há evidências que o uso de alguns fitoativos retardam sintomas variados causados pelo climatério. Entretanto, a planta que será abordada neste trabalho é conhecida por sua funcionalidade para a redução da causa que mais acomete as mulheres a partir de uma certa idade. Trata-se da Morus Nigra, planta que possui um bom embasamento cientifico de comprovação terapêutica, o que é de extrema importância para o tratamento de qualquer enfermidade. Objetivos: Desenvolver uma revisão sistemática sobre os medicamentos à base de fitoterapiteraia que utilizam a Morus Nigra para o tratamento dos sintomas da menopausa, evidenciando também o climatério. Metodologia: é uma pesquisa básica, que objetiva gerar conhecimentos novos e úteis para o avanço da ciência. Seus objetivos são exploratórios, cuja finalidade é a de proporcionar mais informações sobre o assunto que foi investigado, possibilitando sua definição e seu delineamento. Quanto a sua abordagem, é uma pesquisa qualitativa, que descreve, interpreta e compara

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Section: Resultados E Discussõesunclassified

A fitoterapia Morus Nigra: como alternativa no tratamento dos sintomas da menopausa / Phytotherapy as an alternative in the treatment of menopause symptoms

Rodrigues¹,

Viera²,

Barros³

et al. 2021

BJDV

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“…Overdose or long-term use of certain medications is clearly linked with liver injury, kidney injury, or both. High dosage or chronic use of PCM is a very famous example of this pathology; this analgesic is known as a life-threatening agent due to its both marked hepatic and renal impairment [21]. PCM also induces substantial hematological changes in animals [22].…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with Salvadora persica L. (Miswak) aqueous extract alleviates paracetamol-induced hepatotoxicity, nephrotoxicity, and hematological toxicity in male mice

et al. 2021

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Background and Aim: Paracetamol (PCM) ingestion is one of the most frequent global causes of toxicity. Salvadora persica L. is a plant that among many other effects exhibits potent antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. In this study, we investigated the possible protective effect of S. persica aqueous extract in the PCM overdose-induced liver and kidney injury and hematological changes in a mice model. Materials and Methods: Mice were given PCM with and without S. persica pretreatment. Blood cell counts and liver and kidney function biomarkers were measured. Liver and kidney samples were histologically examined. Results: A single overdose of PCM caused significant elevations of alanine and aspartate transaminases, alkaline phosphate, bilirubin, urea, uric acid, and creatinine compared with the control group. In addition, PCM toxicity significantly lowered red blood cell count but insignificantly increased both white blood cell and platelet counts in comparison to the control mice. Pretreatment with S. persica significantly prevented PCM-induced changes in hepatic and renal biomarkers. S. persica also caused marked reversal of hematological changes. Histologically, the liver and kidney showed inflammation and necrosis after PCM treatment, which were significantly reduced in mice pretreated with S. persica. Conclusion: Taken together, S. persica significantly inhibited PCM-induced renal, hepatic, and hematological toxicity, pointing to its possible use in the treatment of liver and renal disorders.

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“…Pharmaceutical plants represent nowadays an important source of biologically active compounds that are used in many drugs (Diab et al, 2020).Till now; their effects on heritable material are unknown. So in the present study we decided to explore the chemical composition of Lavandula officinalis essential oil.…”

Section: Research Articlementioning

confidence: 99%

Evaluation of the Anti-Cancer/Anti-Mutagenic Efficiency of Lavandula officinalis Essential Oil

Fahmy

Farghaly

Hassan

et al. 2022

Asian Pac J Cancer Prev

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Inhibitory activity of black mulberry (Morus nigra) extract against testicular, liver and kidney toxicity induced by paracetamol in mice

Cited by 19 publications

References 55 publications

A fitoterapia Morus Nigra: como alternativa no tratamento dos sintomas da menopausa / Phytotherapy as an alternative in the treatment of menopause symptoms

A fitoterapia Morus Nigra: como alternativa no tratamento dos sintomas da menopausa / Phytotherapy as an alternative in the treatment of menopause symptoms

Pretreatment with Salvadora persica L. (Miswak) aqueous extract alleviates paracetamol-induced hepatotoxicity, nephrotoxicity, and hematological toxicity in male mice

Evaluation of the Anti-Cancer/Anti-Mutagenic Efficiency of Lavandula officinalis Essential Oil

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