Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains

Abstract

Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.

Activities of Different Classes of Acyclic Nucleoside Phosphonates against BK Virus in Primary Human Renal Cells

“…In a previous study, we investigated the in vitro antiviral activities of three classes of ANPs against primate SV40 and murine polyomavirus (mPyV) in BS-C-1 and UC1-B cells, respectively (27). Among the first class of ANPs, HPMPC and cHPMPC were found to be potent and selective anti-SV40 compounds, with SIs of between 20 and 40, which is consistent with the data that we obtained for BKV.…”

“…These derivatives showed antiviral effects on a broad spectrum of DNA viruses and especially on SV40 and murine polyomavirus (mPyV) (27). In this study, we assayed the three different classes of phosphonate analogues ( Fig.…”

Activities of Several Classes of Acyclic Nucleoside Phosphonates against Camelpox Virus Replication in Different Cell Culture Models

“…The HPMP derivatives bearing the 5-azacytosine moiety also showed high activities and selectivities against murine polyomavirus and the polyomavirus simian virus 40 (30).…”

Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus

“…Several of these derivatives have been evaluated in vitro and ex vivo against poxviruses including VACV, CPXV, CMLV, and orf virus replication (16,17,28,42,46,61). As shown in Fig.…”