Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities

Murata, Kazuya; Noguchi, Kazuma; Kondo, Masato; Onishi, Mariko; Watanabe, Nozomi; Okamura, Katsumasa; Matsuda, Hideaki

doi:10.1007/s11418-011-0570-6

Cited by 38 publications

(25 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PF-ext can stimulate the induction of the hair cycle to anagen phase, but this mechanism has not been proven definitely [105].…”

Section: Puerariae Flosmentioning

confidence: 99%

“…The two major compounds, soyasaponin I and kaikasaponin III, are responsible for this inhibitory activity. In addition to inhibitory activity on testosterone 5α-reductase of both compounds, soyasaponin I possesses hepatoprotective, sialyltransferase inhibitory, and renin inhibitory activities, while kaikasaponin III possesses anti-hepatotoxic, hypoglycemic, hypolipidemic, and anti-herpes virus activities [105,106]. Inhibitory activity of PF-ext on 5α-reductase is stronger than Puerariae Radix extract (PR-ext).…”

Section: Puerariae Flosmentioning

confidence: 99%

See 1 more Smart Citation

Alternative Medicine for Hair Loss

Yardımcı¹

2017

Hair and Scalp Disorders

View full text Add to dashboard Cite

In recent years, people have begun to give further emphasis to the external beauty, especially for their hair. Except drugs with proven effectiveness, complementary and alternative treatment options that have not yet been clarified of their effectiveness and side effect profiles have been used for centuries. Many plants or their extracts are widely used to prevent hair loss and treat alopecia (e.g., androgenetic alopecia, alopecia areata, or traction alopecia) worldwide, especially in Far Eastern countries. The mechanisms of action of these plants are still unknown. Although there are little randomized-controlled studies investigating the effectiveness in the treatment of hair loss, reported results have demonstrated that complementary and alternative medicine will become much more popular in the near future.

show abstract

“…PF-ext can stimulate the induction of the hair cycle to anagen phase, but this mechanism has not been proven definitely [105].…”

Section: Puerariae Flosmentioning

confidence: 99%

Section: Puerariae Flosmentioning

confidence: 99%

Alternative Medicine for Hair Loss

Yardımcı¹

2017

Hair and Scalp Disorders

View full text Add to dashboard Cite

show abstract

“…The 50% ethanolic extract of Puerariae Flos (the flowers of Pueraria thomsonii) showed inhibitory activity of 60.2% at 500 µg/ml against testosterone 5α-reductase and it was more potent than that of Puerariae radix (roots of Pueraria lobata) [20]. E .…”

Section: Plant Raw Materialsmentioning

confidence: 99%

Plants as potential active components in treatment of androgenetic alopecia

et al. 2014

View full text Add to dashboard Cite

S u m m a r yAndrogenetic alopecia is caused by the influence of sex hormones on hair follicles and by hereditary factors. Characteristic for that type of alopecia is shortening of the hair growth phase and elongation of the rest phase caused by disturbance of the process of transformation of testosterone into dihydrotestosterone. Treatment of that type of alopecia involves 5α-reductase inhibitors, antagonists of the androgenic receptor or stimulating proliferation of cells to induce the hair growth. A number of plant raw materials work that way, thus they can be used in treatment of this type of alopecia.

show abstract

“…Some 5αR inhibitors from natural products have been discovered by our group, i.e., 12-methoxycarnosic acid in Rosmarinus officinalis leaf,[19] ginsenoside Ro in the rhizome of red ginseng,[20] kaikasaponin and soyasaponin in flowers of Pueraria thomsonii [21] and fatty acids and ethinylestradiol in spores of Lygodium japonicum . [22]…”

Section: Introductionmentioning

confidence: 99%

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

Murata¹,

Hayashi²,

Matsumura³

et al. 2013

Phcog Res

Self Cite

View full text Add to dashboard Cite

Background:Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5α-reductase (5αR) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice.Materials and Methods:Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5αR inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger's method. The K. parviflora extract was administered to castrated mice for 14 days.Results:K. parviflora extract showed more potent inhibitory activity on 5αR than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days.Conclusion:These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH.

show abstract

Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities

Cited by 38 publications

References 23 publications

Alternative Medicine for Hair Loss

Alternative Medicine for Hair Loss

Plants as potential active components in treatment of androgenetic alopecia

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

Contact Info

Product

Resources

About