Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes

Deveci, Ebru; Çayan, Fatih; Tel‐Çayan, Gülsen; Duru, Mehmet Emin

doi:10.1016/j.sajb.2020.09.039

Cited by 35 publications

(27 citation statements)

References 32 publications

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“…The weakest amylase inhibitory effect was shown by G. resinaceum (0.13 mmol ACAE/g). In an earlier study by Deveci et al [ 37 ], the amylase inhibitory effect of the hexane extract of G. adspersum at the concentration of 1 mg/mL was found to be 96.96%. In the same study, however, the methanolic extract at the same concentration demonstrated an inhibitory effect of 14.40%.…”

Section: Resultsmentioning

confidence: 98%

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

et al. 2022

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Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable research materials. They also enable constant control and adaptation of the process, thereby leading to increased biomass growth and accumulation of bioactive metabolites. The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G. applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. The presence of phenolic acids, amino acids, indole compounds, sterols, and kojic acid in biomass extracts was determined by HPLC. The antioxidant and cytotoxic activities of the extracts and their effects on the inhibition of selected enzymes (tyrosinase and acetylcholinesterase) were also evaluated. The total content of phenolic acids in the extracts ranged from 5.8 (G. carnosum) to 114.07 mg/100 g dry weight (d.w.) (G. pfeifferi). The total content of indole compounds in the extracts ranged from 3.03 (G. carnosum) to 11.56 mg/100 g d.w. (G. lucidum) and that of ergosterol ranged from 28.15 (G. applanatum) to 74.78 mg/100 g d.w. (G. adspersum). Kojic acid was found in the extracts of G. applanatum and G. lucidum. The tested extracts showed significant antioxidant activity. The results suggest that the analyzed mycelial cultures are promising candidates for the development of new dietary supplements or pharmaceutical preparations.

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Section: Resultsmentioning

confidence: 98%

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

et al. 2022

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“…Anti‐acetylcholinesterase (AChE), anti‐butyrylcholinesterase (BChE), anti‐urease, anti‐tyrosinase, anti‐α‐glucosidase and anti‐α‐amylase activities were tested as described in our previous reports (Deveci et al ., 2019a; Deveci et al ., 2021). Galantamine, kojic acid, thiourea and acarbose were used as standards.…”

Section: Methodsmentioning

confidence: 99%

“…This is the first report related to anti-urease activities of all isolated compounds. Anti-a-amylase and anti-a-glucosidase activity a-Amylase and a-glucosidase are responsible for the digestion of the carbohydrates and inhibiting these enzymes are important strategy for treatment of type 2 diabetes (Deveci et al, 2021). Anti-a-glucosidase and anti-a-amylase activities of the isolated compounds were given in Table 2.…”

Section: Anti-urease Activitymentioning

confidence: 99%

A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomycesparvulosporus

Çayan

Tel‐Çayan

Deveci

et al. 2021

Int J of Food Sci Tech

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Mushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the combination of chromatographic techniques. Fumaric acid (54.74 AE 0.85 µg g À1 ) was found as the major compound by HPLC-DAD. All isolated compounds were bioassayed for antioxidant, cytotoxic, anticholinesterase, antityrosinase, anti-urease, anti-a-glucosidase and anti-a-amylase activities. Compound 1 indicated notable cytotoxic activity on MCF-7 (IC 50 : 38.08 AE 0.75 µg mL À1 ) and compound 3 on H1299 (IC 50 : 62.37 AE 0.75 µg mL À1 ). Also, compounds 1 (84.55 AE 1.14%) and 2 (84.90 AE 0.10%) showed higher antiurease activity than thiourea (78.57 AE 0.22%), while compound 2 (66.31 AE 0.08%) displayed nearstandard anti-BChE activity. Also, being the first to emphasise the potential of R. parvulosporus as a natural food additive, this study evidenced its medicinal importance by revealing bioactive compounds and properties.

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“…In this context, Deveci et al . (2021) assessed twenty‐four mushrooms to study their antidiabetic potential and the behaviour on α‐amylase and α‐glucosidase, both associated with type 2 diabetes. The results confirmed this raw material as promising agents through key enzyme inhibition.…”

Section: Bioactive Properties From Mushroomsmentioning

confidence: 99%

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

López‐Hortas

Flórez‐Fernández

Torres

et al. 2022

Int J of Food Sci Tech

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The traditional and growing importance of mushrooms due to their rich composition in nutritive and bioactive compounds converts the whole feedstock and their fractions into versatile attractive ingredients for food and nutraceuticals. The processing conditions are critically relevant to selectively recover highvaluable compounds in a sustainable way. This short review, covering scientific papers published in the last 2 years, offers an updated vision of the study and applications of edible mushroom bioactive compounds, covering aspects in relation to the novelties in the cultivation, isolation, identification, characterisation of chemical and biological properties, extraction technologies and purification, as well as food applications, particularly in novel foods.

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Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes

Cited by 35 publications

References 32 publications

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomycesparvulosporus

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

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