Inhibitory action of forearm flexor muscle afferents on corticospinal outputs to antagonist muscles in humans

Bertolasi, Laura; Priori, Alberto; Tinazzi, Michèle; Bertasi, Valeria; Rothwell, John C.

doi:10.1111/j.1469-7793.1998.947bg.x

Cited by 104 publications

(86 citation statements)

References 31 publications

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“…Reciprocal inhibition between the flexors and extensors, found to play a significant role in the control of forearm muscles, 9,12 has been shown to be compromised following stroke. 7 The requirements for proper coordination of flexor and extensor motoneurons for the finger muscles are assuredly even greater than those for the forearm due to the complex firing patterns required for finger manipulation.…”

Section: Reflex Contributions To Resistance To Extensionmentioning

confidence: 99%

Quantitative features of the stretch response of extrinsic finger muscles in hemiparetic stroke

Kamper¹,

Rymer²

2000

Muscle Nerve

115

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Despite its potential importance in hand dysfunction, spasticity in the finger muscles following stroke has not been well described. To explore this area, we assessed the role of finger flexor spasticity, along with that of passive mechanical forces, in resisting finger movement in 13 chronic stroke subjects. Subjects were tested with a device that stretched the extrinsic finger muscles through imposed rotation of the metacarpophalangeal (MCP) joints. Both maintained and constant-velocity stretches were imposed. For the constant-velocity stretches, eight of the 13 stroke subjects exhibited strong stretch reflexes, as determined by electromyography and net work. The net work of this reflex response, calculated from the integral of the torque-angle plots, increased proportionally with increasing velocity, indicating a contribution from flexor muscle spasticity. Conversely, nine of the 13 stroke subjects did not possess distinctly greater passive, mechanical resistance to MCP rotation than control subjects. While extensor spasticity was not observed, stretch of the extrinsic finger flexors also produced some reflex activity in the finger extensors concomitant with reflex excitation of the flexors. These findings suggest that resistance to muscle stretching following stoke is mediated primarily by neurological rather than biomechanical disturbances, although changes in muscle fiber length may exaggerate the resistance.

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Section: Reflex Contributions To Resistance To Extensionmentioning

confidence: 99%

Quantitative features of the stretch response of extrinsic finger muscles in hemiparetic stroke

Kamper¹,

Rymer²

2000

Muscle Nerve

115

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show abstract

“…Contudo, em face dos achados negativos de redução na IR, a rigidez muscular pode ser explicada por alterações supramedulares características da DP 8,13 . É possível que as áreas do córtex motor que controlam músculos antagonistas são organizadas de maneira semelhante à IR em nível espinhal, como entradas a partir da contração de músculos agonistas não só excitam as suas áreas correspondentes, mas também inibem as áreas que controlam os antagonistas 30 . Outra segunda possibilidade está no argumento que as vias descendentes provindas do córtex motor e do tronco encefálico que convergem para os interneurônios e mediam a IR dissináptica 26,[31][32] , podem estar alteradas em indivíduos com DP 9 devido à disfunção dos núcleos da base 9 .…”

Section: Discussionunclassified

Comparação de inibições medulares entre indivíduos com doença de Parkinson e saudáveis

Silva‐Batista

Ugrinowitsch

Yoshida

et al. 2013

Rev. bras. educ. fís. esporte

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O objetivo do presente estudo foi comparar os níveis de inibição pré-sináptica (IPS) e inibição recíproca (IR) entre indivíduos com Doença de Parkinson e saudáveis e, a correlação entre essas inibições e a rigidez muscular e a severidade clínica de indivíduos com Doença de Parkinson (avaliadas através da Escala Unificada de Avaliação da Doença de Parkinson). Foram avaliados 11 indivíduos nos estágios 2 e 3 da doença e 13 indivíduos saudáveis pareados pela idade. A IPS foi menor em indivíduos com Doença de Parkinson (31,6%) do que em saudáveis (67,1%) (p = 0,02). A IR não diferiu entre indivíduos com Doença de Parkinson (26,9%) e saudáveis (27,6%) (p = 0,91). Adicionalmente, não foram detectadas correlações entre os níveis de IPS com a rigidez e a severidade clínica (p > 0,05). Portanto, mecanismos inibitórios não explicam totalmente a rigidez muscular e a severidade clinica da doença. Alterações entre ativação de músculos agonistas e antagonistas parecem estar relacionadas a influências supraespinhais anormais nos mecanismos espinhais decorrentes da doença.

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“…iPD patients have defective agonist-antagonist activation patterns, which was expressed as lack of inhibition to extensor coupled interneurons during flexion compared to healthy persons (Meunier et al, 2000). This defective 1a-inhibition in iPD seems to be modulated at both cortical (Bertolasi et al, 1998) and subcortical level (Meunier et al, 2000), in particular in the subthalamic nucleus (Raoul et al, 2012). Accordingly, common supraspinal input was described to synchronize the antagonistic spinal motor neuron pools to a common frequency.…”

Section: Discussionmentioning

confidence: 99%

“…A distinct impairment of antagonistic spinal reciprocal inhibition via inhibitory 1a-interneurons was demonstrated (Meunier et al, 2000). Moreover, both cortical (Bertolasi et al, 1998) and subcortical modulatory influences (Raoul et al, 2012) on antagonistic motor control were revealed.…”

Section: Introductionmentioning

confidence: 94%

Neuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson’s disease

Scholten

Klotz

Plewnia

et al. 2016

Clinical Neurophysiology

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Inhibitory action of forearm flexor muscle afferents on corticospinal outputs to antagonist muscles in humans

Cited by 104 publications

References 31 publications

Quantitative features of the stretch response of extrinsic finger muscles in hemiparetic stroke

Quantitative features of the stretch response of extrinsic finger muscles in hemiparetic stroke

Comparação de inibições medulares entre indivíduos com doença de Parkinson e saudáveis

Neuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson’s disease

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