Inhibitors of the Renin‐Angiotensin System (RAS) Completely Prevents Cardiac Hypertrophy (CH) Induced by Ischemic Renal Injury (IRI) via Angiotensin II (AngII)/Toll‐Like Receptors (TLR) Cross‐Talk
Abstract:ObjectivesThe cardio‐renal syndrome comprises a set of pathophysiological kidney‐heart interactions. Renal injury promotes release of inflammatory cytokines (CTK), which may act through cardiac TLR and lead to CH, as well as AngII. This study aims to investigate a possible interaction between TLR and RAS in CH model induced by IRI.MethodsC57BL/6 male mice (n=84) treated with Losartan (Los‐10 mg/kg) or Enalapril (Ena‐40 mg/kg) were subjected to surgical occlusion of left renal pedicle and kept under observation… Show more
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