Inhibitors of the Fibrinolytic Enzyme System in Renal Disease

Abstract

1. Levels of serum inhibitor of plasminogen activation, anti-plasmin and plasminogen activator were measured in normal subjects and patients with active glomerulonephritis and chronic renal failure.2. Patients with active glomerulonephritis all had grossly elevated levels of serum inhibitor of plasminogen activation and significant elevation of anti-plasmin. The majority of activator levels lay at the lower end of the normal range.3. Patients with chronic renal failure had significantly elevated levels of serum inhibitor of plasminogen activation and anti-plasmin, but the changes were less marked than in those with active glomerulonephritis. Activator levels were consistently reduced.4. The marked inhibition of fibrinolysis in active glomerulonephritis may be a factor in the persistence of glomerular fibrin and ultimately in perpetuation of renal damage. The changes in the fibrinolytic system in chronic renal failure may determine the development of the serosal exudates characteristic of that condition.

Fibrinogen Levels in Hypertensive and Normotensive: A Cross-Sectional Study from El-Obied City, Sudan

“…This result was in agreement with several studies conducted among hypertensive patients [8] [11] [12]. Also this finding is contrary to the findings reported by other workers [13] [14]. Although Sechi et al did not observe differences in fibrinogen between hypertensive patients and normotensive controls, their study demonstrated a strong and independent association between fibrinogen and the presence and severity of hypertension related damage in different target organs [15].…”

Intravascular coagulation andE. colisepticaemia

“…Of interest is the increased activity of urokinase inhibitor, demonstrated in seven of the eight patients. A similar abnormality has previously been reported in the serum of individuals with various renal disorders (Bennett and Ogston, 1970) and it is possible that the development of this inhibitor is related to the deposition of fibrin within the glomerular capillaries.…”

The fibrinolytic enzyme system in hypertension

“…However, it is evident from table I that a trend in mean values of each parameter was similar in the hypertensive and normotensive patients with renal disease. Rastogi, 1970;Bennett and Ogston, 1970), but their relationship to the development of hypertension was not considered in these studies. The relationship of changes in the fibrinolytic enzyme system to the development of hypertension is not clear.…”