The grain-oriented silicon steel was produced by medium temperature reheating and two-stage cold rolling process, and the microstructure and texture of all metallurgical processes were studied. The results shown that the microstructure of the hot rolled strip was inhomogeneous in thickness direction, the surface layer was the recrystallized microstructures with average grain size of 42.29 µm, the center layer was fiber structure, and the Goss texture appeared at surface. The primary recrystallized microstructure with average grain size of 16 µm was obtained after decarburization annealing, which characterized by a strong γ-fiber texture and a weak Goss texture. The average size of inhibitors in hot rolled strip and decarburization annealed sheet were 9.078 and 21.691 nm respectively, they were mainly compound of nitride and sulfide with spherical or lump shapes. The coarse Goss grains with average size 17.57 mm were got after secondary recrystallization, and the magnetic induction B8 and iron loss P1.7/50 were 1.885 T and 1.10 W/Kg, respectively.