Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response

Thoetkiattikul, Honglada; Beck, Markus H.; Strand, Michael R.

doi:10.1073/pnas.0505240102

Cited by 140 publications

(146 citation statements)

References 46 publications

Supporting

Mentioning

141

Contrasting

Order By: Relevance

“…At least three virsuses -African swine fever virus (ASFV) (Powell et al, 1996), rabbit myxoma virus (CamusBouclainville et al, 2004), insect Microplitis demolitor bracovirus (Thoetkiattikul et al, 2005) -encode IkB-like inhibitors of NF-kB. In the case of ASFV, the viral A238L IkB-like protein lacks the analogous serine residues that direct signal-induced phosphorylation and degradation of cellular IkBs, and thus, A238L can stably interact with RelA to inhibit NF-kB DNA binding as induced by TNFa, IFN-g and phorbol ester (Revilla et al, 1998).…”

Section: Nf-jb Inhibitors Encoded or Produced By Viruses Bacteria Anmentioning

confidence: 99%

Inhibitors of NF-κB signaling: 785 and counting

2006

View full text Add to dashboard Cite

Section: Nf-jb Inhibitors Encoded or Produced By Viruses Bacteria Anmentioning

confidence: 99%

Inhibitors of NF-κB signaling: 785 and counting

2006

View full text Add to dashboard Cite

“…There are also some differences between IVs and BVs. IVs genomes have more but smaller genome segments than BVs, as visualized on agarose gels; BV virions vary in length, with multiple nucleocapsids often observed within the singly enveloped virions (Thoetkiattikul, Beck, and Strand, 2005;Tortorella et al, 2000).…”

Section: Polydnavirus-derived Immunosuppressive Genesmentioning

confidence: 99%

“…The vankyrin gene family is the only gene family present in both IV and BV genomes (Thoetkiattikul, Beck, and Strand, 2005). The ubiquitous presence of vankyrin genes suggests an underlying importance for activities of these genes in both…”

Section: Polydnavirus-derived Immunosuppressive Genesmentioning

confidence: 99%

“…segments that are packaged in multiprotein capsids surrounded by a single (Bracovirus, BVs) or double (Ichnovirus, IVs) lipid envelope (Thoetkiattikul, Beck, and Strand, 2005). There are some similarities in DNA composition and structure between these two genomes, such as the genome size of IV and BV, virus segments of both groups exhibit hypermolarity and contain sequences that cross-hybridize to multiple segments.…”

Section: Polydnavirus-derived Immunosuppressive Genesmentioning

confidence: 99%

“…The vankyrin gene family consists of seven members encoded on two unique CsIV segments P and I 2 , which contain ankyrin repeat domains Thoetkiattikul, Beck, and Strand, 2005).…”

Section: Polydnavirus-derived Immunosuppressive Genesmentioning

confidence: 99%

See 2 more Smart Citations

Tissue specificity of a baculovirus-expressed, basement membrane-degrading protease in larvae of Heliothis virescens

Tang

Lei

et al. 2007

Tissue and Cell

View full text Add to dashboard Cite

Evolution of Immune Proteins in Insects

Bulmer

2010

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

Insect immune proteins evolve more rapidly than nonimmune proteins. Based largely on genetic studies in Drosophila species, this elevated rate appears to be due to adaptive evolution in only a small subset of immune proteins. The genetic signature of adaptive evolution is apparently a response by the host to interference or evasion of the immune system by pathogens, which are usually unknown. In contrast, many insect immune proteins appear to be constrained not to change because they interact with conserved molecular targets in a pathogen's cell wall or plasma membrane. Adaptive immune protein evolution may be attributable to a sustained arms race between host and pathogen or to rapid environmental change that exposes insects to new pathogen suites. Evidence of a correlation between the strength of selection and functional divergence in antimicrobial peptides provides confirmation that the inferred genetic signatures of adaptive evolution reflect a response to pathogen selective pressure. Key Concepts: A small set of immune proteins in Drosophila evolve much more rapidly than other proteins. Insect antiviral proteins of the RNA interference system are among the top 3% of rapidly evolving proteins in Drosophila. There is surprisingly little evidence of adaptive evolution in Drosophila antimicrobial peptides. Many receptors and effectors of the insect immune system appear to be evolutionary constrained due to their interaction with conserved target molecules. Pathogens target certain vulnerable immune proteins for suppression and positive selection in these proteins appears to reflect a counter response to this suppression. The selective pressure imposed by pathogens appears to be greater for social than nonsocial insects. Rapid changes in the types of pathogen that hosts encounter as well as long‐term co‐evolutionary arms races may drive adaptive immune protein evolution. Positive selection appears to drive the functional divergence of antimicrobial peptides in termites and other animals.

show abstract

Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response

Cited by 140 publications

References 46 publications

Inhibitors of NF-κB signaling: 785 and counting

Inhibitors of NF-κB signaling: 785 and counting

Tissue specificity of a baculovirus-expressed, basement membrane-degrading protease in larvae of Heliothis virescens

Evolution of Immune Proteins in Insects

Contact Info

Product

Resources

About