Inhibitor of DNA Binding Protein 3 (ID3) and Nuclear Respiratory Factor 1 (NRF1) Mediated Transcriptional Gene Signatures are Associated with the Severity of Cerebral Amyloid Angiopathy

Perez, Christian Michael; Gong, Zhenghua; Yoo, Changwon; Roy, Deodutta; Deoraj, Alok; Felty, Quentin

doi:10.1007/s12035-023-03541-2

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Aβ Production1

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2023

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“…Interestingly, men have more severe CAA than women [242]. Perez et al have recently shown that the transcription-regulating protein inhibitor of the DNA-binding protein 3 (ID3) is associated with CAA severity in women, while the nuclear respiratory factor 1 (NRF1) is associated with CAA severity in men [243], potentially providing new targets for personalized medicine and/or prevention strategies against CAA.…”

Section: Aβ Productionmentioning

confidence: 99%

Minding the Gap: Exploring Neuroinflammatory and Microglial Sex Differences in Alzheimer’s Disease

Reed,

Keller-Norrell

2023

IJMS

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Research into Alzheimer’s Disease (AD) describes a link between AD and the resident immune cells of the brain, the microglia. Further, this suspected link is thought to have underlying sex effects, although the mechanisms of these effects are only just beginning to be understood. Many of these insights are the result of policies put in place by funding agencies such as the National Institutes of Health (NIH) to consider sex as a biological variable (SABV) and the move towards precision medicine due to continued lackluster therapeutic options. The purpose of this review is to provide an updated assessment of the current research that summarizes sex differences and the research pertaining to microglia and their varied responses in AD.

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Section: Aβ Productionmentioning

confidence: 99%