Abstract:Hepatitis C Virus (HCV) is the key cause of chronic and severe liver diseases. The recent direct-acting antiviral agents have shown the clinical success on HCV-related diseases, but the rapid HCV mutations of the virus highlight the sustaining necessity to develop new drugs. p7, the viroporin protein from HCV, has been sought after as a potential anti-HCV drug target. Several classes of compounds, such as amantadine and rimantadine have been testified for p7 inhibition. However, the efficacies of these compoun… Show more
“…temsirolimus (predicted pIC50 = 11.06), an antineoplastic agent is reported to be in phase II trial for the advanced hepatocellular carcinoma treatment [55] . Similarly, from NS5A predicted drugs, rimantadine (predicted pIC50 = 11.06) a RNA synthesis inhibitor, is experimentally tested as HCV viroporin inhibitor [56] . Vildagliptin (predicted pIC50 = 11.06) a dipeptidyl peptidase 4 inhibitor, is experimentally validated for its activity against hepatocellular carcinoma progression [57] .…”
“…temsirolimus (predicted pIC50 = 11.06), an antineoplastic agent is reported to be in phase II trial for the advanced hepatocellular carcinoma treatment [55] . Similarly, from NS5A predicted drugs, rimantadine (predicted pIC50 = 11.06) a RNA synthesis inhibitor, is experimentally tested as HCV viroporin inhibitor [56] . Vildagliptin (predicted pIC50 = 11.06) a dipeptidyl peptidase 4 inhibitor, is experimentally validated for its activity against hepatocellular carcinoma progression [57] .…”
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