Abstract:The
protein homeostasis (proteostasis) network is composed of multiple
pathways that work together to balance protein folding, stability,
and turnover. Cancer cells are particularly reliant on this network;
however, it is hypothesized that inhibition of one node might lead
to compensation. To better understand these connections, we dosed
22Rv1 prostate cancer cells with inhibitors of four proteostasis targets
(Hsp70, Hsp90, proteasome, and p97), either alone or in binary combinations,
and measured the effects … Show more
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