Inhibition of yeast growth by molybdenum-hydroxylamido complexes correlates with their presence in media at differing pH values

Crans, Debbie C.; Smee, Jason J.; Gaidamauskiene, Edita G.; Anderson, Oren P.; Miller, Susie M.; Jin, Wenzheng; Gaidamauskas, Ernestas; Crubellier, Etienne; Grainda, Rose; Har, Lai; Willsky, Gail R.

doi:10.1016/j.jinorgbio.2004.08.010

Cited by 16 publications

(8 citation statements)

References 46 publications

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“…Although the coordination chemistry of unmodified hydroxylamine and its alkyl-substituted derivatives with molybdenum and vanadium was extensively studied, the ligation of molybdenum and vanadium , with chelating hydroxylamino (chehyl) ligands remains surprisingly unexplored.…”

Section: Introductionmentioning

confidence: 99%

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H₂bihyat. Water-Assisted Activation of the Mo^VI═O Bond and Reversible Dimerization of cis-[Mo^VIO₂(bihyat)] to [Mo^VI₂O₄(bihyat)₂(H₂O)₂]

et al. 2012

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Reaction of the N,N-disubstituted bis(hydroxylamino) ligand 2,6-bis[hydroxy(methyl)amino]-4-morpholino-1,3,5-triazine (H(2)bihyat) with cis-[Mo(VI)O(2)(acac)(2)] in tetrahydrofuran resulted in isolation of the mononuclear compound cis-[Mo(VI)O(2)(bihyat)] (1). The treatment of Na(2)Mo(VI)O(4)·2H(2)O with the ligand H(2)bihyat in aqueous solution gave the dinuclear compounds cis-[Mo(VI)(2)O(4)(bihyat)(2)(H(2)O)(2)] (2) and trans-[Mo(VI)(2)O(4)(bihyat)(2)(H(2)O)(2)] (3) at pH values of 3.5 and 5.5, respectively. The structures for the three molybdenum(VI) compounds were determined by X-ray crystallography. Compound 1 has a square-pyramidal arrangement around molybdenum, while in the two dinuclear compounds, each molybdenum atom is in a distorted pentagonal-bipyramidal environment of two bridging and one terminal oxido groups, a tridentate (O,N,O) bihyat(2-) ligand that forms two five-membered chelate rings, and a water molecule trans to the terminal oxido group. The dinuclear compounds constitute rare examples containing the {Mo(2)(VI)O(2)(μ(2)-O(2))}(4+) moiety. The potentiometry revealed that the Mo(VI)bihyat(2-) species exhibit high hydrolytic stability in aqueous solution at a narrow range of pH values, 3-5. A subtle change in the coordination environment of the five-coordinate compound 1 with ligation of a weakly bound water molecule trans to the oxido ligand (1w) renders the equatorial oxido group in 1w more nucleophilic than that in 1, and this oxido group attacks a molybdenum atom and thus the dinuclear compounds 2 and 3 are formed. This process might be considered as the first step of the oxido group nucleophilic attack on organic substrates, resulting in oxidation of the substrate, in the active site of molybdenum enzymes such as xanthine oxidase. Theoretical calculations in the gas phase were performed to examine the influence of water on the dimerization process (1 → 2/3). In addition, the molecular structures, cis/trans geometrical isomerism for the dinuclear molybdenum(VI) species, vibrational spectra, and energetics of the metal-ligand interaction for the three molybdenum(VI) compounds 1-3 have been studied by means of density functional theory calculations.

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Section: Introductionmentioning

confidence: 99%

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H₂bihyat. Water-Assisted Activation of the Mo^VI═O Bond and Reversible Dimerization of cis-[Mo^VIO₂(bihyat)] to [Mo^VI₂O₄(bihyat)₂(H₂O)₂]

et al. 2012

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“…It is interesting that complexation protects the microorganisms, again consistent with the free ligand being more potent than the complex. While inert Mo compounds are the least effective at inhibiting yeast growth, Mo-dimethylhdroxylamido complex is the most effective [39]. These results show that the formation of some Mo complexes can protect yeast from the growth inhibition observed when either the ligand or Mo salt alone is present [39].…”

Section: Antimicrobial Activitymentioning

confidence: 76%

“…While inert Mo compounds are the least effective at inhibiting yeast growth, Mo-dimethylhdroxylamido complex is the most effective [39]. These results show that the formation of some Mo complexes can protect yeast from the growth inhibition observed when either the ligand or Mo salt alone is present [39]. But this effect was not observed for the vanadium insulin-enhancing compounds [10][11].…”

Section: Antimicrobial Activitymentioning

confidence: 87%

Synthesis, spectroscopic, thermal, voltammetric studies and biological activity of crystalline complexes of pyridine-2,6-dicarboxylic acid and 8-hydroxyquinoline

Çolak

Yeşılel

et al. 2009

Journal of Molecular Structure

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“…Some oxido‐peroxidomolybdenum(VI) complexes have been found to catalyze the two electron oxidation of Br − to Br + in presence of H 2 O 2 and thus are considered as functional mimics of vanadium bromoperoxidases ,. Various other oxidomolybdenum and molybdenum carboxylate complexes have also been found to exhibit biomimicking properties …”

Section: Introductionmentioning

confidence: 99%

Biomimicking Oxidative Bromination and DNA Nuclease Activities of a New Structurally Characterised Oxido-Diperoxidomolybdenum(VI) Complex

et al. 2017

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A new oxido‐diperoxido molybdenum complex, [MoO(O2)2(AA)]PPh4 (AA=anthranilic acid) has been designed and synthesized. The Structural characterisation suggests that the molybdenum centre is heptacoordinated with a slight distorted pentagonal bipyramidal geometry. The pentagonal plane is completed with four oxygen atoms from two peroxido moiety and one oxygen atom from the ligand carboxylate group. Among the two axial positions one is occupied by an oxygen atom of the oxido group and the other is occupied by an oxygen atom from the ligand carboxylate moiety. The biomimicking multifunctionality of this molybdenum(VI) complex has been exhibited by the application of it as a catalyst in peroxidative bromination, whereas the nuclease activity has been established by DNA cleavage. The catalytic studies suggest that the present compound is a good biological peroxidase mimic. The DNA binding of the molybdenum complex has been studied by various physicochemical tools like UV–vis, fluorescence, viscosity. The intrinsic binding constant of the complex with DNA is calculated to be (8.14 ± 0.03) x103 M−1. All the physicochemical studies and the viscosity measurements reveal that the complex is a groove binder to CT‐DNA. The extent of ability of the complex to induce DNA cleavage was studied by gel electrophoresis techniques. The complex has been found to exhibit cleavage of pUC19 plasmid DNA with good efficiency.

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Inhibition of yeast growth by molybdenum-hydroxylamido complexes correlates with their presence in media at differing pH values

Cited by 16 publications

References 46 publications

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H₂bihyat. Water-Assisted Activation of the Mo^VI═O Bond and Reversible Dimerization of cis-[Mo^VIO₂(bihyat)] to [Mo^VI₂O₄(bihyat)₂(H₂O)₂]

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H₂bihyat. Water-Assisted Activation of the Mo^VI═O Bond and Reversible Dimerization of cis-[Mo^VIO₂(bihyat)] to [Mo^VI₂O₄(bihyat)₂(H₂O)₂]

Synthesis, spectroscopic, thermal, voltammetric studies and biological activity of crystalline complexes of pyridine-2,6-dicarboxylic acid and 8-hydroxyquinoline

Biomimicking Oxidative Bromination and DNA Nuclease Activities of a New Structurally Characterised Oxido-Diperoxidomolybdenum(VI) Complex

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Inhibition of yeast growth by molybdenum-hydroxylamido complexes correlates with their presence in media at differing pH values

Cited by 16 publications

References 46 publications

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H2bihyat. Water-Assisted Activation of the MoVI═O Bond and Reversible Dimerization of cis-[MoVIO2(bihyat)] to [MoVI2O4(bihyat)2(H2O)2]

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H2bihyat. Water-Assisted Activation of the MoVI═O Bond and Reversible Dimerization of cis-[MoVIO2(bihyat)] to [MoVI2O4(bihyat)2(H2O)2]

Synthesis, spectroscopic, thermal, voltammetric studies and biological activity of crystalline complexes of pyridine-2,6-dicarboxylic acid and 8-hydroxyquinoline

Biomimicking Oxidative Bromination and DNA Nuclease Activities of a New Structurally Characterised Oxido-Diperoxidomolybdenum(VI) Complex

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Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H₂bihyat. Water-Assisted Activation of the Mo^VI═O Bond and Reversible Dimerization of cis-[Mo^VIO₂(bihyat)] to [Mo^VI₂O₄(bihyat)₂(H₂O)₂]

Molybdenum(VI) Coordination Chemistry of the N,N-Disubstituted Bis(hydroxylamido)-1,3,5-triazine Ligand, H₂bihyat. Water-Assisted Activation of the Mo^VI═O Bond and Reversible Dimerization of cis-[Mo^VIO₂(bihyat)] to [Mo^VI₂O₄(bihyat)₂(H₂O)₂]